This retrospective-prospective bidirectional cohort study aims to observe ocular parameter changes, different surgical/vision recovery strategies and postoperative adverse effects among young children with cataract. The influence on psychology and cognitive function will be taken into consideration as well.
Pediatric cataract, one of the leading causes of childhood blindness globally, is complex and of great difficulty in treatment. Pediatric patients with cataract (congenital, traumatic or complicated) are enrolled. In this study, investigators will compare ocular parameter changes, different surgical/vision timing or recovery strategies and adverse effects among young children （age \< 18 yo）before and after cataract surgery. The influence on psychology and cognitive function will be taken into consideration as well. The whole blood samples of participants and parents are collected and retained in our biobank for gene sequencing, hoping to explore the genetic factors in association with pathogenesis. For children received cataract surgery, samples of partial anterior capsular tissue and 1 ml aqueous humor were collected during operation for further analysis. Multimodal artificial intelligence analyses are performed to establish accurate diagnosis/treatment scheme and disease prediction model.
Study Type
OBSERVATIONAL
Enrollment
5,000
Zhongshan Ophthalmic Center
Guangzhou, Guangdong, China
RECRUITINGBest-corrected visual acuity changes
Best-corrected visual acuity changes are measured by visual acuity charts (Teller/Lea symbol/ETDRS chart) every 1 year at scheduled time
Time frame: Baseline and through study completion, an average of 1 year
Intraocular pressure changes
Intraocular pressures are measured by NCT machine
Time frame: Baseline and through study completion, an average of 1 year
Refractive power changes
Refractive power are measured at baseline and every visit at least every 1 year
Time frame: Baseline and through study completion, an average of 1 year
Ocular biological measurements changes
Ocular biological measurements including axial length, corneal keratometry, anterior chamber angle/depth, corneal endothelial cell number and appearance
Time frame: Baseline and through study completion, an average of 1 year
Incidence changes of postoperative complications
Incidence of postoperative complications, such as glaucoma-related adverse, myopic shift, strabismus and anisometropia and so on
Time frame: Baseline and through study completion, an average of 1 year
Other factors changes
Sleep, depression, cognitive function are measured by questionnaires. Self-Rating Scale of Sleep: minimum value-1 point, maximum value-50, and higher scores mean worse outcome. Hamilton Depression Scale: \<7 points-normal, and higher scores mean worse outcome. Loewenstein Cognitive Assessment: for every question, minimum 1 point, and maximum 4 points. Higher scores mean worse outcomes.
Time frame: Baseline and through study completion, an average of 1 year
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BMI changes
BMI is measured by technicians in every visit
Time frame: Baseline and through study completion, an average of 1 year
Blood pressure changes
Diastolic and systolic blood pressure are measured by technicians in every visit
Time frame: Baseline and through study completion, an average of 1 year
Stereopsis changes
Stereopsis is measured by Randot Stereotest
Time frame: Baseline and through study completion, an average of 1 year
Optical coherence tomography (OCT) changes
Retinal thickness is measured and analyzed by OCT
Time frame: Baseline and through study completion, an average of 1 year