Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise

University of British Columbia20 enrolled

Overview

Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function. The proposed study aims to have participants perform submaximal and maximal cycling exercise protocols exposed to both O3 and room air in a crossover design to evaluate how ventilatory patterns, pulmonary function, development of symptoms, and cycling performance are impacted by O3 exposure. Additionally, the investigators look to compare responses between O3 at rest and during exercise to predict which subjects may be most susceptible to adverse response, as considerable interindividual variability exists.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Ozone Exposure During Rest and Exercise

Interventions

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy males between the age of 18 and 50 * Currently training and/or competing in endurance sport * VO2max \>60 ml/kg/min * Able to communicate sufficiently using the English language Exclusion Criteria: * History of smoking * Upper respiratory tract infection within the last 4 weeks * Presence of any chronic respiratory disease

Outcomes

Primary Outcomes

Time-to-exhaustion on Maximal Cycling Bout

Measurement of time (in seconds) to volitional exhaustion on a constant work-rate cycling trial at 110% of previously determined maximal power output.

Time frame: From the beginning of the maximal constant work-rate cycling bout until volitional exhaustion occurs (roughly 1-5 minutes)