Perioperative Outcomes of Simultaneous Colorectal and Liver Resections

Fondazione Poliambulanza Istituto Ospedaliero766 enrolled

Overview

The use of a simultaneous resection in patients with synchronous colorectal liver metastases has increased over the past decades. However, it remains unclear when a simultaneous resection is beneficial and when it should be avoided. The objective of this retrospective study is therefore to compare the outcomes of a simultaneous resection for synchronous colorectal liver metastases in different settings, and to assess which factors are independently associated with unfavorable outcomes.

Study Type

OBSERVATIONAL

Enrollment

766

Conditions

Colorectal Cancer Metastatic Surgical Procedure, Unspecified

Interventions

Major liver resectionPROCEDURE

Major liver resection (3 or more contiguous segments)

Technically major liver resectionPROCEDURE

Minor liver resection (\<3 contiguous segments) in the posterosuperior segments (segment 1,4a,7,8)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elective minimally invasive or open simultaneous resection of colorectal cancer and synchronous colorectal liver metastases Exclusion Criteria: * (Partially) robotic-assisted or thoracoscopic procedures * First stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) * Patients that underwent major concurrent procedures

Locations (1)

Fondazione Poliambulanza Istituto Ospedaliero

Brescia, Lombardy, Italy

Outcomes

Primary Outcomes

Major complications

Severe complications (Clavien-Dindo grade 3a or higher) related to the surgical procedure

Time frame: 30 days postoperatively

Secondary Outcomes

Overall complications

Overall complications related to the surgical procedure

Time frame: 30 days postoperatively

Length of hospital stay

The length of hospital stay for the surgical procedure

Time frame: 30 days postoperatively

R0 resection margin

Proportion of patients in whom a microscopically radical resection of both the primary colorectal carcinoma and the liver metastases was performed.

Time frame: 30 days postoperatively

Intraoperative blood loss

Intraoperative blood loss in milliliters

Time frame: During the surgical procedure

Operative time

Operative time in minutes

Time frame: During the surgical procedure

Conversion to open surgery

Intra-operative conversion to an open or hand-assisted procedure in the minimally invasive group

Time frame: During the surgical procedure

Mortality

Postoperative mortality

Time frame: 90 days postoperatively

Data from ClinicalTrials.gov

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