To evaluate the efficacy and safety of JPI-547, a PARP/TNKS dual inhibitor in Platinum-resistant, advanced/relapsed ovarian cancer subjects previously treated with a PARP inhibitor
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
58
Poly-(ADP-ribose) polymerase (PARP) \& tankyrase (TNKS) inhibitor. * The investigational product (IP) will be administered once daily for 28 days (4 weeks) with 1 cycle. * 1 capsule (JPI-547 150 mg) will be administered once daily at the same time (e.g., a fixed time in the morning) in a fasted condition within 2 hours before or after a meal.
National Cancer Center
Gyeonggi-do, South Korea
Objective Response Rate(ORR)
To evaluate the objective response rate (ORR) in accordance with the Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1.
Time frame: From date of study enroll until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 40 months
Anti-tumor activity
To evaluate the anti-tumor activity in accordance with RECIST v1.1.
Time frame: From date of study enroll until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 40 months
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