With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an important health burden in China. The pathophysiological mechanism of renal injury caused by metabolic diseases has always been a hotspot of research. Currently, it is believed that various mechanisms including the activation of Renin-Angiotensin-Aldosterone System, vascular endothelial dysfunction, oxidative stress and inflammatory process may be involved. Although there are differences in renal pathological manifestations caused by different metabolic diseases, the kidney will eventually present ischemic changes and fibrosis with the progression of the disease. So there must be some common pathogenesis. This study is designed to build a disease cohort of patients with chronic kidney disease caused by metabolic diseases, to identify risk factors leading to disease progression and to explore biomarkers for early diagnosis and treatment of kidney damage.
Study Type
OBSERVATIONAL
Enrollment
200
Blood,urine and imaging biomarkers for early diagnosis and prediction of prognosis.
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
RECRUITINGNumber of Participants with End Stage Renal Disease
End Stage Renal Disease
Time frame: 3 years
Number of Participants with Adverse cardiovascular events
Adverse cardiovascular events
Time frame: 3 years
Number of Participants with all cause death
All cause death
Time frame: 3 years
Number of Participants with eGFR decline
the decline of eGFR during follow-up
Time frame: 3 years
Number of Participants with Complications of CKD
The complications of CKD
Time frame: 3 years
Life quality assessment with short form-36 (SF-36)
The SF-36 is a patient-reported instrument designed to assess overall health status; it is usually utilized to measure patients' quality of life and used primarily in research. Increasing SF-36 scores are indicative of improving health status.
Time frame: 3 years
Advanced Intelligence Assessment with Mini-Mental State Examination (MMSE)
The MMSE is scored on a 30-point scale, with items that assess orientation (temporal and spatial; 10 points), memory (registration and recall; 6 points), attention/concentration (5 points), language (verbal and written; 8 points), and visuospatial function (1 point) . While different cutoff points have been used across studies, scores ≤23 are most commonly regarded as abnormal and indicative of cognitive impairment.
Time frame: 3 years
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