Treatment Benefits of Berberine Supplementation for Women With PCOS

Inclusion Criteria: 1. Women aged between 18 and 45 years 2. PCOS diagnosis as per the Rotterdam Criteria (any two of the following features: * Irregular periods (allso called oligomenorrea) or no periods (amenorrhea), * Higher levels of andregens present in the blood (hyperandrogenism), or physical characteristics of elevated andregen levels such as acne, male-pattern balding, or excess hair growth on face, chin, or body * Polycystic ovaries visible on an ultrasound 3. Normal, over-weight, and obese class I women (BMI 18.5 - 29.9 kg/m2, BMI cut-off as per the Asian criteria) 4. With no desire for pregnancy within 6 months 5. Able to give informed written consent Exclusion Criteria: 1. Women who are currently taking or have teken in the last three months medications known to alter insulin physiology, oral contraceptives, ovulation induction drugs, anti- obesity or cholestrol lowering drugs, or any supplement known to interfere with insulin and androgen metabolism such as inositols, curcumin, lipoic acid, cinnamon, gymnemic and other botanical extracts. 2. Women undergoing in vitro fertilization treatment. 3. Women diagnosed with lateonset congenital adrenal hyperplasia (17-OH progestrone), thyroid disorders, hyperprolactinemia, diabetes mellitus and ODST. 4. Presence of liver, or renal disease 5. Pregnant or lactating or menopause women