HIV-1 & Coronavirus-Coinfection in Europe: Morbidity & Risk Factors of COVID-19 in People Living With HIV

Number of Composite Primary End Point (Critical Care Admission, Palliative Discharge When Discharged From Hospital, or Mortality Within the 6 Weeks After Diagnosis of COVID-19) Events

The primary endpoint is a composite of the number of critical care admission (high dependency unit or intensive care unit), mortality in hospital or palliative discharge when discharged from hospital, or mortality at 6 weeks after diagnosis of COVID-19 or at discharge from hospital (where applicable) events. Time-to-event methods, including Kaplan-Meier survival curves and Cox proportional-hazards models, will be used for this analysis. The time to the primary endpoints will be defined as: * For participants admitted to critical care Time = \[Date of Critical care admission - Date of positive PCR test for COVID-19\] + 1 * For participants admitted to critical care before diagnosis of COVID-19, Time=1 day. * For participants with palliative discharge when discharged from hospital Time = \[Date of discharge from hospital to palliative care - Date of positive PCR test for COVID-19\] + 1. * For participants died Time = \[Date of death - Date of positive PCR test for COVID-19\] + 1.

Time frame: From baseline (diagnosis of COVID-19) to Week 6

Kaplan-Meier Estimate of Primary End Point

Kaplan-Meier estimate of the composite number of critical care admission, palliative discharge and death events

Time frame: From Baseline (diagnosis of COVID-19 ) to week 6

Number of Palliative Discharge

Number of palliative discharge at discharge from hospital following hospitalisation for COVID-19 events

Time frame: Baseline (diagnosis of COVID-19) to week 6

Mortality

Mortality at 6 weeks after diagnosis of COVID-19 or at discharge from hospital

Time frame: Baseline (diagnosis of COVID-19) to week 6

Number of Critical Care Admission Events

Number of admission events to a high dependency unit or intensive care unit

Time frame: Baseline (diagnosis of COVID-19) to week 6

HIV Viral Load

Identification of risk factors for COVID-19 infection within the group of PLHIV: HIV viral load

Time frame: Baseline(Last CD4 cell count and HIV-RNA before COVID-19 diagnosis, or most recent for PLHIV without COVID-19)

Time Since HIV Diagnosis

Identification of risk factors for COVID-19 infection within the group of PLHIV: Time since HIV diagnosis

Time frame: Baseline(Last CD4 cell count and HIV-RNA before COVID-19 diagnosis, or most recent for PLHIV without COVID-19)

Chronic Obstructive Pulmonary Disease

Identification of risk factors for COVID-19 infection within the group of PLHIV: Chronic Obstructive Pulmonary Disease

Time frame: Baseline(Last CD4 cell count and HIV-RNA before COVID-19 diagnosis, or most recent for PLHIV without COVID-19)

CD4 Cell Count

Identification of risk factors for COVID-19 infection within the group of PLHIV: CD4 cell count

Time frame: Baseline(Last CD4 cell count and HIV-RNA before COVID-19 diagnosis, or most recent for PLHIV without COVID-19)

Chronic Kidney Disease

Identification of risk factors for COVID-19 infection within the group of PLHIV: Chronic Kidney Disease

Time frame: Baseline(Last CD4 cell count and HIV-RNA before COVID-19 diagnosis, or most recent for PLHIV without COVID-19)

Body Weight

Identification of risk factors for COVID-19 infection within the group of PLHIV: Body weight

Time frame: Baseline(Last CD4 cell count and HIV-RNA before COVID-19 diagnosis, or most recent for PLHIV without COVID-19)