All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion. Vancomycin dosage, age, weight and serum creatinin will be recorded. Seven pharmacokinetic models' predictive performance will be evaluated on this database. Using the best model, we will perform Monte-Carlo simulation to elaborate dosing nomograms and develop dosing recommandations of continuous infusion of vancomycin.
Monte Carlo simulations will be performed according to varying creatinin clearance values and weight, for both the loading dose and the maintenance dose.
Study Type
OBSERVATIONAL
Enrollment
300
Brest University Hospital
Brest, France
Imprecision in Predictive performance of seven pharmacokinetic models
The model with the lesser imprecision reported on the Observed vs Predicted Concentrations Graph will be selected
Time frame: September 2021
Bias in Predictive performance of seven pharmacokinetic models
The model with the lesser bias reported on the Observed vs Predicted Concentrations Graph will be selected
Time frame: September 2021
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