The recent four RCTs evaluating effects of RBC storage age on morbidity and mortality found no statistically significant adverse effects of longer stored RBC compared to shorter storage ages. Unfortunately, none of these RCTs had sufficient numbers of subjects receiving RBC at either storage age extreme to identify consequences of RBC transfusion at these limits. To better investigate effects of RBC storage age on clinical outcomes, this study will perform secondary meta-analyses of merged common patient data elements -individual patient data (IPD) meta-analysis (IPDMA) - from the nearly 33,000 subjects enrolled in the four RCTs.
Study Type
OBSERVATIONAL
Enrollment
33,000
This is an observational retrospective study (meta-analysis)
University of Minnesota
Minneapolis, Minnesota, United States
All-cause mortality
Estimate the effect of transfused RBC storage-age on time to all-cause mortality
Time frame: 28 days after transfusion
Hospital length of stay
Estimate the effect of transfused RBC storage-age on hospital stay
Time frame: after transfusion through 28 days
All-cause mortality at 28 days for long-storage
all-cause mortality at 28 days comparing subjects who received (one or more) RBC unit ≥ 35 days vs. no unit \> 35 days
Time frame: 28 days after transfusion
28 day mortality for short-storage
28 day mortality for subjects who received (one or more) RBC unit ≤ 7 days vs. no unit ≤ 7 days
Time frame: 28 days after transfusion
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