VEGF in Iris Tissue in Primary Congenital Glaucoma

Hassan Lotfy Fahmy30 enrolled

Overview

Estimation of vascular endothelial growth factor (VEGF) in iris tissue specimen in primary congenital glaucoma through Immunohistochemistry.

Combined trabeculotomy with mitomycin C will done in infants with primary congenital glaucoma with histopathological examination of the the peripheral iris tissue specimen and vascular endothelial growth factor (VEGF) estimation in iris tissue specimen through Immunohistochemistry. Estimation of vascular endothelial growth factor (VEGF) in iris tissue specimen taking from ocular trauma or congenital cataract used as control.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Iris

Interventions

Immunohistochemistry analysisOTHER

Estimation of VEGF through Immunohistochemistry

Eligibility

Sex: ALLMin age: 1 DayMax age: 1 Year

Medical Language ↔ Plain English

Inclusion Criteria: * primary congenital glaucoma Exclusion Criteria: * Infants with history of previous surgery. * Secondary glaucoma. * Glaucoma associated with other congenital anomalies.

Locations (1)

Hassan Lotfy

Asyut, Egypt

Outcomes

Primary Outcomes

VEGF

Estimation of VEGF grade in iris tissue through Immunohistochemistry, The grades is arranged from 0 to 5, with 0 being the lowest level and 5 being the highest level

Time frame: 6 month

Data from ClinicalTrials.gov

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