Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Surgical resection is the main treatment option for colorectal cancer patients. Surgery may enhance or accelerate tumor recurrence and metastasis. Multiple factors in the tumor microenvironment play important roles in tumor recurrence and metastasis, and modulating the tumor microenvironment can inhibit disease progression. Lidocaine has been found to inhibit tumor growth in animal experiments.
Lidocaine was applied in the operation of colorectal tumor patients, and the effect on the postoperative microenvironment and micrometastasis of the patients was observed by detecting the stress, immunity, vascular tumor regeneration, inflammation, etc. of the patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
100
Administer 1.5 mg/kg lidocaine
Affiliated Hospital of Nantong University
Nantong, Jiangsu, China
the concentration of tumor micrometastasis markers were determined by ELISA
the concentration of tumor micrometastasis markers such as CK20 was determined by ELISA
Time frame: 3 days after surgery
the concentration of stress hormones were determined by ELISA
the concentration of EPI and NE were determined by ELISA
Time frame: 3 days after surgery
the concentration of inflammatory factor were determined by ELISA
the concentration of IL-6,IL-8,TNF-α were determined by ELISA
Time frame: 3 days after surgery
the concentration of angiogenesis factors were determined by ELISA
the concentration of VEGF was determined by ELISA
Time frame: 3 days after surgery
the concentration of immune indexes were determined by ELISA
the concentration of B lymphocytes, T lymphocytes, NK cells, macrophages were determined by ELISA
Time frame: 3 days after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.