Antibodies and Immunity After Vaccination of Recovered Patients With COVID-19 and Long COVID-19 Symptoms

Mahidol University305 enrolled

Overview

We investigated the association between immune system responsibilities in Long COVID patients and Full recovery patients.

This retrospective cohort study compared immunogenicity post COVID-19 between individuals (aged 18-65 years and had confirmed SARS-CoV-2 infection from January to May 2022 ) with residual Long COVID-19 symptoms (LC) and ones with full recovery (Full) related to pathophysiology, immunology and clinical consequence.

Study Type

OBSERVATIONAL

Enrollment

305

Conditions

Long COVID-19

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Long COVID group; at longer than 1-month post COVID-19 based the presence of one of the three following symptoms: fatigue/myalgia, breathlessness, and anorexia * Full recovery group; patients with asymptomatic symptoms * post COVID-19 they had not received any additional COVID vaccine Exclusion Criteria: * people who received additional vaccination after leaving quarantine before the day of the immunization test * pregnant patients, * people who had a history of allergic reactions after COVID-19 vaccination or any drugs

Locations (1)

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok Noi, Bangkok, Thailand

Outcomes

Primary Outcomes

Anti-SARS-CoV-2 RBD IgG

anti-SARS-CoV-2 receptor-binding domain immunoglobulin G(BAU/mL)

Time frame: Baseline

Anti-SARS-CoV-2 NP

surrogate Virus Neutralization Test (sVNT) (PRNT50 titer)

Time frame: Baseline

Microneutralization assays

Microneutralization assays using the authentic SARS-CoV-2 viruses

Time frame: Baseline

Secondary Outcomes

Number of vaccine injection

Time frame: Baseline

Prevalence of Long COVID-19 symptoms

Number of participants with major Long COVID-19 symptoms including fatigue/myalgia, breathlessness, and anorexia by using the questionnaire

Time frame: Baseline

Data from ClinicalTrials.gov

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