Reinforcing Effects of Marijuana and Opioids

Shanna Babalonis, PhD8 enrolled

Overview

The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for each drug.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Marijuana Use Opioid Use

Interventions

MarijuanaDRUG

Double-blind administration of marijuana

OpioidDRUG

Double-blind administration of an opioid agonist

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ages 18-50 * Experience with marijuana and opioids * General good health * Willing to live at the University of Kentucky Hospital (research unit) for approx. 6.5 weeks (meals are provided, Exclusion Criteria: * Significant medical complications/conditions

Locations (1)

University of Kentucky

Lexington, Kentucky, United States

Outcomes

Primary Outcomes

Self-Administration

The number of units of drug earned in each session

Time frame: Collected once during each self-administration session

Secondary Outcomes

Subjective measures

Ratings of drug effects (e.g., feeling high, impaired, good drug effects)

Time frame: Baseline, post-dose during each session (change from baseline is assessed); visual analog scales will be the primary measure (0-100, 0=not at all, 100=extremely)

Heart rate

Beats per minute

Time frame: Baseline, post-dose during each session (change from baseline is assessed)

Blood pressure

Systolic and diastolic blood pressure (mm/hg)

Time frame: Baseline, post-dose during each session (change from baseline is assessed)

Data from ClinicalTrials.gov

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