The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for each drug.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
8
University of Kentucky
Lexington, Kentucky, United States
Self-Administration of Drug Units Earned
The number of units of drug (out of a total of 7) earned in each experimental condition. Participants work for some, none, or all of the available drug dose. For each dose condition, the number of drug units completed for drug was pulled from the raw data and averaged to yield one mean (SEM).
Time frame: Through a progressive-ratio self-administration model given once per treatment condition throughout each 6 hour session
Peak End-tidal Carbon Dioxide (EtCO2)
End-tidal Carbon Dioxide (EtCO2): For each dose condition, the participants' peak value was pulled from the raw data and averaged to yield one mean (SEM). Higher scores indicate greater impairment.
Time frame: This outcome was recorded prior to and in regular intervals after drug administration for the duration of each session (approximately 6 hours).
Trough Respiration Rate
Respiration rate (number of breaths per minute): For each dose condition, the participants' trough value was pulled from the raw data and averaged to yield one mean (SEM). Lower scores indicate greater impairment.
Time frame: This outcome was recorded prior to and in regular intervals after drug administration for the duration of each session (approximately 6 hours).
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