Daily Chlorexidine Bath for Health Care Associated Infection Prevention

Hospital do Coracao15,730 enrolled

Overview

Cluster randomized controlled trial comparing two bathing strategies in critically ill patients. The intervention group will receive daily bathing with chlorhexidine. The control group will receive usual care.

Healthcare-associated infections (HAI) are common complications in critically ill patients and are associated with increased costs, higher length of stay, and higher morbimortality. Data shows that daily chlorhexidine baths might be associated with lower HAI rates in a broad population of critically ill patients. The purpose of this trial is to evaluate the effect of daily bathing with chlorhexidine compared to usual baths (soap and water) on HAI in critically ill patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

15,730

Conditions

Health Care Associated Infection Ventilator Associated Pneumonia Central Line-associated Bloodstream Infection (CLABSI)Catheter-Associated Urinary Tract Infection

Interventions

2% chlorhexidine digluconate solution with surface-active agentsOTHER

Bathing will be performed at least daily using 2% chlorhexidine digluconate solution with surface-active agents on all applicable bathing surfaces, which consists of the entire body surface of the patient except eyes, inner ear, oral mucosa, and areas of loss of skin continuity (such as burnt areas, pressure injuries, etc.); These areas will be bathed according to each center current practice.

Usual BathsOTHER

Bathing will be performed at least daily using soap and water (performed according to the current practice in each center) on all applicable bathing surfaces, which consists of the entire body surface of the patient except eyes, inner ear, oral mucosa, and areas of loss of skin continuity (such as burnt areas, pressure injuries, etc.); These areas will be bathed according to each center current practice.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients ≥ 18 years/old admitted to the participants's ICUs Exclusion Criteria: * History of chlorhexidine allergy

Locations (16)

Hospital Maternidade São José - UNESC - Fundação Social Rural de Colatina

Colatina, Espírito Santo, Brazil

Hospital da Bahia

Salvador, Estado de Bahia, Brazil

Outcomes

Primary Outcomes

Composite of healthcare-associated infections (HAI)

Composite outcome of the following HAI: Ventilator associated pneumonia (VAP) Central line-associated blood stream infections (CLABSI) Catheter-associated urinary tract infection (CAUTI)