The main objective of the study is to improve subjective sleep quality using a multimodal intervention with an intervention and a control group. The multimodal intervention aims to improve circadian Zeitgeber strength. This will be achieved by optimizing daily light exposure, sleep, physical activity, and mealtimes.
The study lasts for 14 months and contains 6 visits. After the screening visit at the Centre for Chronobiology, Basel, Switzerland, participants are assigned to either the intervention or the control group which is followed by a 7-day baseline week at home and a co-design meeting to provide instructions to the intervention and the control group. At the occasion of 2 visits (spread over 6 months) at the participants' homes, different measurements will be performed such as saliva collection, questionnaires, cognitive performance tests, light and rest-activity measures. After the last visit at home, participants come for the second blood sample at the study centre. A follow-up visit 6 months after completion of the last data collection will provide qualitative feedback by the participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
66
Participants in the intervention group will receive personalised advice on sleep, light exposure, meal times and physical activity.
General sleep advice
Centre for Chronobiology, Psychiatric Hopspital of the University of Basel
Basel, Switzerland
Subjective sleep quality
Pittsburgh Sleep Quality Index (Score \> 5 indicates poor sleep)
Time frame: 6 months
Sleep timing
Derived from Activity Watches
Time frame: 6 months
Subjective wellbeing
Visual Analogue Scales
Time frame: 6 months
Salivary melatonin concentration
Circadian phase marker
Time frame: 6 months
Pupil size
Pupil response to chromatic light stimuli
Time frame: 6 months
Glucose metabolism
HbA1c concentration (blood)
Time frame: 6 months
Telomere length
Age marker
Time frame: 6 months
Neuropsychological Battery to assess working memory and attention (including n-back, Psychomotor Vigilance Test)
Cognitive Function
Time frame: 6 months
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