This is an observational, prospective, multicenter, cohort study in patients with cardioembolic stroke and previous oral or parenteral anticoagulant therapy. Patients in which anticoagulante therapy is mantained will be compared to those in which it is interrupted, in terms of stroke or systemic embolism and haemorrhagic transformation.
Observational, prospective, multicenter, cohort study in patients with recent cardioembolic stroke (\<24 hours) and previous oral or parenteral anticoagulant therapy (last dose recieved \<24hours) . Patients in which anticoagulante therapy is mantained will be compared to those in which it is interrupted. The decision to mantain or interrumpt the anticoagulant therapy is made by the treating physician as hospital protocol. Stroke recurrence, haemorrhagic transformation at 90 days are evalauted and also complication during the hospitalization and functional outcome.
Study Type
OBSERVATIONAL
Enrollment
318
Patients are observed for stroke or systemic embolism and haemorrhagic transformation
Bichat Claude Bernard Hospital
Paris, France
ACTIVE_NOT_RECRUITINGJimenez Diaz Fundation University Hospital
Madrid, Spain
RECRUITINGLa Paz University Hospital
Madrid, Spain
RECRUITINGIschemic stroke recurrence
recurrence of ischemic stroke noticied by changes in neurologic status and supported by neuroimaging
Time frame: 90 days
Symptomatic haemorrhagic transformation
Symptomatic haemorrhagic transformation defined by the SITS criteria and supported by neuroimaging
Time frame: 90 days
Early ischemic stroke recurrence
Recurrence of ischemic stroke at days 1 or day 7
Time frame: Day 1 or day 7
Early symptomatic haemorrhagic transformation
Symptomatic transformation ocurring on day 1 or day 7
Time frame: Day 1 or day 7
Early radiologic haemorrhagic transformation
Parenchymal haematoma (type PH1 or PH2) on control neuroimaging performed at 24h (if mechanical thromectomy performed) and at day 7
Time frame: Day 1 or day 7
Systemic embolism
Clinical, radiologic or analytic findings that suggest an ischemic event (myocardic, renal, splenic, bowl or limb infarctions
Time frame: Day 1, day 7 or day 90
Major extracraneal haemorrhagic complication
intraocular, intraspinal, pericardic, intra-articular, intra-muscular with compartimental syndrome, retro-peritoneal bleeding that requires surgery or that causes death. Definition according to ISTH criteria
Time frame: Day 1, day 7 or day 90
Mortality
Death
Time frame: Day 7
Neurologic status
NIHSS scale
Time frame: Day 90
Functional status
modified Rankin scale
Time frame: Day 90
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