Diagnostic performance of low-dose chest CT scan combined with lung-RADS classification (version 1.1) for lung cancer screening among former and current smokers.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
1,000
baseline, 1-year, 3-year and 5-year low-dose CT scan
Hôpital Saint Joseph
Marseille, France
RECRUITINGPositive Predictive Value (PPV)
Time frame: 5 years
Sensitivity
Time frame: 5 years
Specificity
Time frame: 5 years
Early stage lung cancer detection rate (stage I and II)
Time frame: 5 years
5-year survival rate of patients who have undergone thoracic surgery
Time frame: 5 years
Rate of smoking-related co-morbidities detected on low-dose CT scan
smoking-related co-morbities = pulmonary emphysema, interstitial lung disease, atheromatous disease, hepatic steatosis and ascending aortic aneurysm.
Time frame: 5 years
Rate of additional examinations (including invasive diagnostic tests and surgery with benign results)
Time frame: 5 years
Risk ratio of lung cancer
Time frame: 5 years
Number of false positive results
Time frame: 5 years
Penetration rate
number of subjects included / number of includible subjects
Time frame: 5 years
Smoking cessation rates
Time frame: 5 years
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EORTC QLQ-C30 score (version 3)
The EORTC Core Quality of Life questionnaire (EORTC QLQ-C30) is designed to measure cancer patients' physical, psychological and social functions. The EORTC QLQ-C30 is composed of 9 multi-item scales: 5 functioning scales (physical, role, cognitive, emotional and social), a global QOL scale, and 3 symptom scales (fatigue, pain and nausea/vomiting). In addition, several single item symptom measures are used. For the five functioning scales and the global quality of life scale, a higher score represents a better level of functioning. For the symptom scales and items, a high score corresponds to a higher level of symptomatology.
Time frame: 5 years