White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). WMH tend to show a peri-basal ganglia pattern in HA, whereas a multiple subcortical spots pattern can be observed in CAA. Periventricular WMH (PVWMH) have been reported to be posterior predominant using a semiautomated segmentation method and logarithmic transformation, not used in daily clinical practice. In these studies including CAA patients, patients initially presented with haemorrhage-related symptoms. In another study analysing PVWMH and cerebral amyloid evidence in patients with mild cognitive impairment, frontal PVWMH burden was associated with high uptake on florbetapir-PET whereas parietal and occipital PVWMH burden was associated with low CSF-amyloid-beta. The aim of this study is the descriptive comparative analysis of the distribution of PVWMH between CAA and HA patients with radiological tools available in daily practice.
Study Type
OBSERVATIONAL
Enrollment
315
None, pure observational study
CHU de Nîmes
Nîmes, France
Distribution of PVWMH
Maximal distance between the outer PVWMH border and the border of the lateral ventricle (on the axis oriented at 90° to the border of the ventricle)
Time frame: Base line, Day 0
Distribution of PVWMH - total PVWMH extent.
The sum of the PVWMH measurements around the four ventricles horns (i.e. bilateral anterior and posteriors horns) resulted in total PVWMH extent.
Time frame: Base line, Day 0
Corpus callosum (CC) WMH
Distance between the border of the third ventricle and the outer border of the WMH on the rostro-caudal axis, resulting in anterior and posterior CC-PVWMH extent measurements.
Time frame: Base line, Day 0
Corpus callosum (CC) WMH - total CC-PVWMH extent.
The sum of the anterior and posterior CC-PVWMH measurements resulted in the total CC-PVWMH extent.
Time frame: Base line, Day 0
Ratios
Calcul of posterior/anterior ratios for both the PVWMH and CC-PVWMH
Time frame: base line, day 0
Anterior PVWMH
Comparison of anterior PVWMH between CAA group and HA group.
Time frame: Base line, Day 0
Posterior PVWMH
Comparison of posterior PVWMH between CAA group and HA group.
Time frame: Base line, Day 0
Total PVWMH
Comparison of total PVWMH between CAA group and HA group.
Time frame: Base line, Day 0
Posterior/anterior PVWMH ratio
Comparison of the posterior/anterior PVWMH ratio between CAA and HA groups.
Time frame: Base line, Day 0
anterior CC-PVWMH
Comparison of anterior CC-PVWMH between CAA group and HA group.
Time frame: Base line, Day 0
Posterior CC-PVWMH
Comparison of posterior CC-PVWMH between CAA group and HA group.
Time frame: Base line, Day 0
Total PVWMH and posterior/anterior CC-PVWMH ratio
Comparison of total PVWMH and posterior/anterior CC-PVWMH ratio between CAA group and HA group.
Time frame: Base line, Day 0
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