Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis

University Medical Centre Ljubljana30 enrolled

Overview

To compare the efficacy of infusion containing insulin and infusion without insulin on reduction of triglycerides in acute hypertriglyceridemic pancreatitis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypertriglyceridemia Acute Pancreatitis

Interventions

insulinBIOLOGICAL

5% glucose in 0.9% NaCl with 4 IU of short acting insulin per 500 ml added, infused at a rate determined by the treating physician, treatment duration: 18 hours

standard treatmentOTHER

infusion of a balanced solution, infused at a rate determined by the treating physician, treatment duration: 18 hours

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute pancreatitis * triglycerides \> 15 mmol/l Exclusion Criteria: * diabetes on peroral therapy or insulin * blood glucose \> 11 mmol/l * pregnancy

Outcomes

Primary Outcomes

%triglyceride reduction

change in triglycerides, expressed as % of initial value

Time frame: after 18 hours of treatment

Secondary Outcomes

incidence of hypoglycemia

Time frame: during treatment with insulin, up to day 5

Central Contacts

Samo Plut, MD

CONTACT

00386 1 522 4165 samo.plut@kclj.si

Data from ClinicalTrials.gov

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