The aim of this trial is to investigate whether regular endurance exercise during the lactation period will influence breastmilk composition among individuals with overweight/obesity, and secondarily to assess if such changes impact the growth and health of the infants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
62
Supervised endurance training with moderate-to-high intensity 3-4 times weekly.
Dept Circulation and Medical Imaging, EXCAR Exercise Lab
Trondheim, Norway
RECRUITINGBreastmilk human milk oligosaccharide (HMO) 3'sialyllactose (3'SL)
Relative concentration of 3'SL in breastmilk
Time frame: 0 to 8 weeks
Breastmilk human milk oligosaccharide (HMO) 3'sialyllactose (3'SL)
Relative concentration of 3'SL in breastmilk
Time frame: 0 to 4 weeks
Breastmilk metabolites
Relative concentrations of metabolites in breastmilk determined using untargeted metabolomics profiling (mass spectrometry)
Time frame: 0 to 8 weeks
Breastmilk metabolites
Relative concentrations of metabolites in breastmilk determined using untargeted metabolomics profiling (mass spectrometry)
Time frame: 0 to 4 weeks
Breastmilk microRNA
RNA sequencing
Time frame: 0 to 8 weeks
Breastmilk microRNA
RNA sequencing
Time frame: 0 to 4 weeks
Maternal insulin sensitivity
Homeostatic model assessment of insulin resistance (HOMA-IR)
Time frame: 0 to 8 weeks
Maternal fasting circulating insulin C-peptide concentrations
From fasting venous blood sampling
Time frame: 0 to 8 weeks
Maternal fasting circulating glucose concentrations
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
From fasting venous blood sampling
Time frame: After 9 months from baseline
Maternal circulating total cholesterol concentrations
From fasting venous blood sampling
Time frame: 0 to 8 weeks
Maternal circulating total cholesterol concentrations
From fasting venous blood sampling
Time frame: After 9 months from baseline
Maternal circulating high-density lipoprotein (HDL) concentrations
From fasting venous blood sampling
Time frame: 0 to 8 weeks
Maternal circulating high-density lipoprotein (HDL) concentrations
From fasting venous blood sampling
Time frame: After 9 months from baseline
Maternal circulating low-density lipoprotein (LDL) concentrations
From fasting venous blood sampling
Time frame: 0 to 8 weeks
Maternal circulating low-density lipoprotein (LDL) concentrations
From fasting venous blood sampling
Time frame: After 9 months from baseline
Maternal circulating triglycerides concentrations
From fasting venous blood sampling
Time frame: 0 to 8 weeks
Maternal circulating triglycerides concentrations
From fasting venous blood sampling
Time frame: After 9 months from baseline
Maternal glycated hemoglobin (HbA1c)
From fasting venous blood sampling
Time frame: 0 to 8 weeks
Maternal glycated hemoglobin (HbA1c)
From fasting venous blood sampling
Time frame: After 9 months from baseline
Maternal circulating high-sensitivity c-reactive protein
From fasting venous blood sampling
Time frame: 0 to 8 weeks
Maternal circulating high-sensitivity c-reactive protein
From fasting venous blood sampling
Time frame: After 9 months from baseline
Maternal total body mass
Impedance scale
Time frame: 0 to 8 weeks
Maternal total body mass
Impedance scale
Time frame: After 9 months from baseline
Maternal fat mass
Impedance scale
Time frame: 0 to 8 weeks
Maternal fat mass
Impedance scale
Time frame: After 9 months from baseline
Maternal fat-free mass
Impedance scale
Time frame: 0 to 8 weeks
Maternal fat-free mass
Impedance scale
Time frame: After 9 months from baseline
Maternal visceral fat area
Impedance scale
Time frame: 0 to 8 weeks
Maternal visceral fat area
Impedance scale
Time frame: After 9 months from baseline
Maternal bone mass
Impedance scale
Time frame: 0 to 8 weeks
Maternal bone mass
Impedance scale
Time frame: After 9 months from baseline
Maternal waist circumference
Measuring tape
Time frame: 0 to 8 weeks
Maternal waist circumference
Measuring tape
Time frame: After 9 months from baseline
Maternal cardiorespiratory fitness
Maximum oxygen uptake via direct gas exchange
Time frame: 0 to 8 weeks
Maternal cardiorespiratory fitness
Maximum oxygen uptake via direct gas exchange
Time frame: After 9 months from baseline
Maternal systolic blood pressure
Automatic cuff
Time frame: 0 to 8 weeks
Maternal systolic blood pressure
Automatic cuff
Time frame: After 9 months from baseline
Maternal diastolic blood pressure
Automatic cuff
Time frame: 0 to 8 weeks
Maternal diastolic blood pressure
Automatic cuff
Time frame: After 9 months from baseline
Maternal nutrition
Diet diary completed for four days at baseline and at study completion
Time frame: 0 to 8 weeks
Maternal physical activity
Number of steps per week, self-reported (questionnaire)
Time frame: 0 to 8 weeks
Maternal physical activity
Number of steps per week, self-reported (questionnaire)
Time frame: After 9 months from baseline
Maternal physical activity
Minutes of moderate-intensity physical activity per week, self-reported (questionnaire)
Time frame: 0 to 8 weeks
Maternal physical activity
Minutes of high-intensity physical activity per week, self-reported (questionnaire)
Time frame: After 9 months from baseline
Maternal psychological well-being
Self-reported (questionnaire)
Time frame: 0 to 8 weeks
Maternal psychological well-being
Self-reported (questionnaire)
Time frame: After 9 months from baseline
Infant total body mass
Impedance scale
Time frame: 0 to 8 weeks
Infant total body mass
Impedance scale
Time frame: After 9 months from baseline
Infant fat mass
Impedance scale
Time frame: 0 to 8 weeks
Infant fat mass
Impedance scale
Time frame: After 9 months from baseline
Infant muscle mass
Impedance scale
Time frame: 0 to 8 weeks
Infant muscle mass
Impedance scale
Time frame: After 9 months from baseline
Infant bone density
Impedance scale
Time frame: 0 to 8 weeks
Infant bone density
Impedance scale
Time frame: After 9 months from baseline
Infant hydration status
Impedance scale
Time frame: 0 to 8 weeks
Infant hydration status
Impedance scale
Time frame: After 9 months from baseline
Infant total body mass (trajectories)
From health records
Time frame: Infant age 4 weeks
Infant length (trajectories)
From health records
Time frame: Infant age 4 weeks
Infant head circumference (trajectories)
From health records
Time frame: Infant age 4 weeks
Infant total body mass (trajectories)
From health records
Time frame: Infant age 6 weeks
Infant length (trajectories)
From health records
Time frame: Infant age 6 weeks
Infant head circumference (trajectories)
From health records
Time frame: Infant age 6 weeks
Infant total body mass (trajectories)
From health records
Time frame: Infant age 3 months
Infant length (trajectories)
From health records
Time frame: Infant age 3 months
Infant head circumference (trajectories)
From health records
Time frame: Infant age 3 months
Infant total body mass (trajectories)
From health records
Time frame: Infant age 6 months
Infant length (trajectories)
From health records
Time frame: Infant age 6 months
Infant head circumference (trajectories)
From health records
Time frame: Infant age 6 months
Infant total body mass (trajectories)
From health records
Time frame: Infant age 8 months
Infant length (trajectories)
From health records
Time frame: Infant age 8 months
Infant head circumference (trajectories)
From health records
Time frame: Infant age 8 months
Infant total body mass (trajectories)
From health records
Time frame: Infant age 10 months
Infant length (trajectories)
From health records
Time frame: Infant age 10 months
Infant head circumference (trajectories)
From health records
Time frame: Infant age 10 months
Infant total body mass (trajectories)
From health records
Time frame: Infant age 12 months
Infant height (trajectories)
From health records
Time frame: Infant age 12 months
Infant head circumference (trajectories)
From health records
Time frame: Infant age 12 months
Infant total body mass (trajectories)
From health records
Time frame: Infant age 24 months
Infant height (trajectories)
From health records
Time frame: Infant age 24 months
Infant head circumference (trajectories)
From health records
Time frame: Infant age 24 months
Infant gut microbiota
Sequencing
Time frame: 0 to 4 weeks
Infant gut microbiota
Sequencing
Time frame: 0 to 8 weeks
Infant microRNA
Sequencing
Time frame: 0 to 8 weeks