Clinical Trial of TQB2825 in Subjects With CD20 Positive Hematological Tumors

Inclusion Criteria: * 1 Malignant hematologic tumors, including but not limited to lymphoma, leukemia, myeloma, etc., which are clearly diagnosed by histology or cytology (report of immunotyping results is required). * 2 Immunophenotypic analysis showed CD20 positive. * 3 18 years old ≤ Age ≤75 years old; Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1; Life expectancy ≥ 3 months. * 4 Prior induction or salvage therapy ≥second-line treatment, adequate treatment with at least one regimen containing an anti-CD20 mab (combination chemotherapy or monotherapy), and meeting the following criteria: 1. Patients who have not been alleviated after the last adequate treatment or whose disease has progressed after remission, or who have relapsed after autologous hematopoietic stem cell transplantation (auto-HSCT) 2. Patients with refractory Anti-CD20 monoclonal antibody. * 5 According to the 2014 Lugano criteria, there is at least one measurable lesion, that is, a lymph node lesion with a diameter \>15 mm or an extranodal lesion with a diameter \>10 mm according to the cross-sectional CT image (for tumors with the 2014 Lugano evaluation criteria). * 6 Negative serum/urine pregnancy test within 7 days prior to initial dosing and must be non-lactating subjects; Female subjects of reproductive age agree to use contraception (such as an intrauterine device, birth control pill, or condom) during the study period and for six months after the study ends; Male subjects agreed to use contraception during the study period and for six months after the end of the study period. * 7 The subjects voluntarily joined the study and signed informed consent with good compliance. Exclusion Criteria: * 1 Tumor diseases and medical history: 1. Hematologic malignancies that have or are suspected to involve the central nervous system (CNS) or primary CNS lymphoma; 2. Subjects who had or currently had other malignancies within 3 years. Two conditions can be included in clinical trials: five consecutive years of disease-free survival (DFS) for other malignancies treated with a single operation; Cured cervical carcinoma in situ, non-melanoma skin cancer, and superficial bladder tumors \[Ta (non-invasive tumor), Tis (carcinoma in situ), and T1 (tumor infiltrating basal membrane)\]; 3. Clinically significant uncontrolled pleural effusion ascites requiring repeated drainage and pericardial effusion with medium or higher volume. * 2 Previous anti-tumor therapy: 1. Prior treatment with other antibodies targeting both CD3 and CD20; 2. Received any investigational antibody drug therapy, CAR T therapy, or other immunocytotherapy, or auto-HSCT within 3 months prior to initial administration; 3. Prior allogeneic hematopoietic stem cell transplantation (ALLO-HSCT); 4. Any major surgery, chemotherapy and/or radiotherapy, immunotherapy or targeted therapy within 4 weeks prior to initial administration; 5. The half-life of the first administration is less than 5 drugs from the previous oral targeted therapy (calculated from the end time of the last treatment); 6. Received proprietary Chinese medicines with anticancer indications specified in NMPA approved drug instructions within 2 weeks prior to initial administration; 7. The toxicity of previous antitumor treatment is not recovered to ≤ grade 1(common terminology criteria for adverse events 5.0) . * 3 Associated diseases and medical history: 1. Liver abnormalities: decompensated cirrhosis and active hepatitis; 2. Renal abnormalities: I. Renal failure requiring hemodialysis or peritoneal dialysis; II. Previous history of nephrotic syndrome. 3. Gastrointestinal abnormalities: I. Chronic diarrhea persists despite maximum medical treatment; II. Presence of active inflammatory bowel disease within 4 weeks prior to initial administration. 4. Cardiovascular and cerebrovascular abnormalities: I. With or prior history of central nervous system diseases; II. MRI evidence of brain inflammation and/or vasculitis; III. Occurrence of cerebrovascular accident or cerebral infarction within 6 months before the first administration; IV. Arteriovenous thrombosis events such as deep vein thrombosis and pulmonary embolism occurred within 3 months before the first administration; V. With or prior history of cardiovascular disease; VI. Hypertension that cannot be controlled by the combination of the two drugs (systolic blood pressure ≥160 mmHg and diastolic blood pressure ≥100 mmHg measured at least twice); VII. Previous or current heart valvulitis or endocarditis. 5. Medical history of immunodeficiency: known human immunodeficiency virus (HIV) infection, or other acquired, congenital immunodeficiency disease; 6. Uncontrollable systemic bacterial, fungal or viral infection. 7. Lung disease: I. Previous or present with or suspected chronic obstructive pulmonary disease (COPD) and forced expiratory volume at the end of 1 second (FEV1) \<60% (estimated value); II. Past or present non-infectious pneumonia requiring corticosteroid treatment; IV. Active tuberculosis. 8. History of severe allergies of unknown cause; Known allergy to monoclonal antibodies or to exogenous human immunoglobulin; Known allergy to investigational drug excipients. * 4 Getting a live-attenuated vaccine within 4 weeks prior to initial administration or during planned study period. * 5 Participated in clinical trials of other drugs within 30 days. * 6 It is estimated that the compliance of patients participating in this clinical study is insufficient.