Retrospective analysis of real-world disease outcomes in non-severe COVID-19 patients with high risk factors of progression to severe disease, including death, without definitive anti-SARS-CoV-2 treatment
This is a retrospective, observational, real-world study to review outcomes of Mild to Moderate COVID-19 patients admitted to Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine (hereinafter referred to as Ruijin Hospital) from March to June 2022. These patients should be with risk factors for progression to severe disease (including death) and without definitive anti-novel coronavirus (SARS-CoV-2) treatment. The database of this study will be the hospital information system (HIS) of Ruijin Hospital.
Study Type
OBSERVATIONAL
Enrollment
2,000
Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
RECRUITINGPercentage of patients with COVID-19 progression
Percentage of patients with COVID-19 progression (defined as progression to severe/critical COVID-19 or death from any cause).
Time frame: up to 3 months
Percentage of participants
Percentage of participants who experience these events * Progress to severe COVID-19 * Progress to critical COVID-19 * Death from any cause * Admission to ICU * Mechanical Ventilation * Progress to severe COVID-19 * Progress to critical COVID-19 * Death from any cause * Admission to ICU * Mechanical Ventilation
Time frame: up to 3 months
SARS-CoV-2
Time from first SARS-CoV-2 positive to continuous negative
Time frame: up to 3 months
SARS-CoV-2 continuous negative
Time from admission to SARS-CoV-2 continuous negative
Time frame: up to 3 months
SARS-CoV-2 Ct values
Changes in SARS-CoV-2 Ct values
Time frame: up to 3 months
chest CT scan
Changes in chest CT scan
Time frame: up to 3 months
Length of hospital stay
Length of hospital stay related to COVID-19
Time frame: up to 3 months
safety
Abnormal results of vital signs (respiration)beats per minute
Time frame: up to 3 months
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safety
Abnormal results of vital signs (blood pressure) (mm Hg)
Time frame: up to 3 months
safety
Abnormal results of vital signs (body temperature)(℃)
Time frame: up to 3 months
safety
Abnormal results of vital signs (pulse) (beats per minute)
Time frame: up to 3 months
safety
Abnormal results of laboratory(Hematology, clinical chemistry, urinalysis)
Time frame: up to 3 months
safety
Abnormal results of electrocardiogram: heart rate.
Time frame: up to 3 months
safety
Abnormal results of electrocardiogram: P-R interval
Time frame: up to 3 months
safety
Abnormal results of electrocardiogram: QTcF interval
Time frame: up to 3 months