The main aim and scope of this study is making comparison about the thrombelastography and coagulation function in patients before and after the total knee arthroplasty with intra-articular tranexamic acid administration. The results may identify the influence of the intra-articular tranexamic acid administration on the relative coagulability monitoring.
Study Type
OBSERVATIONAL
Enrollment
54
During the total knee arthroplasty, the patients received a 2-g retrograde injection of tranexamic acid through the drain after closure, with subsequent clamping of the drain for 6 hours.
R time
R time is the period from the initiation of the thrombelastography test till the beginning of the clot formation.
Time frame: day0 (pre-operative)
R time
R time is the period from the initiation of the thrombelastography test till the beginning of the clot formation.
Time frame: day3 (post-operative)
K time
K time is the period from the start of the clot formation to the curve reaches amplitude of 20mm in the thrombelastography.
Time frame: day0 (pre-operative)
K time
K time is the period from the start of the clot formation to the curve reaches amplitude of 20mm in the thrombelastography.
Time frame: day3 (post-operative)
Alpha angle
Alpha angle is the angle between the baseline and the tangent to the thrombelastography curve through the starting point of coagulation.
Time frame: day0 (pre-operative)
Alpha angle
Alpha angle is the angle between the baseline and the tangent to the thrombelastography curve through the starting point of coagulation.
Time frame: day3 (post-operative)
Maximal amplitude (MA)
Maximal amplitude (MA) is a direct measure of the highest point on the thrombelastography curve and represents clot strength.
Time frame: day0 (pre-operative)
Maximal amplitude (MA)
Maximal amplitude (MA) is a direct measure of the highest point on the thrombelastography curve and represents clot strength.
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Time frame: day3 (post-operative)
Clot index (CI)
Clot index (CI) represents the haemostasis profile and is calculated based on R time, K time, Alpha angle and MA parameters.
Time frame: day0 (pre-operative)
Clot index (CI)
Clot index (CI) represents the haemostasis profile and is calculated based on R time, K time, Alpha angle and MA parameters.
Time frame: day3 (post-operative)
Prothrombin time (PT)
Prothrombin time (PT) is one of the parameters which reflects the coagulation function.
Time frame: day0 (pre-operative)
Prothrombin time (PT)
Prothrombin time (PT) is one of the parameters which reflects the coagulation function.
Time frame: day3 (post-operative)
Activated partial thromboplastin time (APTT)
Activated partial thromboplastin time (APTT) is one of the parameters which reflects the coagulation function.
Time frame: day0 (pre-operative)
Activated partial thromboplastin time (APTT)
Activated partial thromboplastin time (APTT) is one of the parameters which reflects the coagulation function.
Time frame: day3 (post-operative)
Hemoglobin in g/L
Hemoglobin is a parameter which reflects the blood loss or anemia.
Time frame: day0 (pre-operative)
Hemoglobin in g/L
Hemoglobin is a parameter which reflects the blood loss or anemia.
Time frame: day3 (post-operative)
Red blood cell specific volume (HCT)
Red blood cell specific volume (HCT) is a parameter which reflects the ratio of the red blood cells in the whole blood.
Time frame: day0 (pre-operative)
Red blood cell specific volume (HCT)
Red blood cell specific volume (HCT) is a parameter which reflects the ratio of the red blood cells in the whole blood.
Time frame: day3 (post-operative)
Fibrinogen in g/L
Fibrinogen is one of the parameters which reflects the coagulation function.
Time frame: day0 (pre-operative)
Fibrinogen in g/L
Fibrinogen is one of the parameters which reflects the coagulation function.
Time frame: day3 (post-operative)
Platelet count in 10^9g/L
Plstelet count is a parameter which reflects the amount of the platelet in the whole blood.
Time frame: day0 (pre-operative)
Platelet count in 10^9g/L
Plstelet count is a parameter which reflects the amount of the platelet in the whole blood.
Time frame: day3 (post-operative)