Preoperative Embolization of Hypervascular Head and Neck Tumors to Improve Surgical Outcomes

Inclusion Criteria: * Primary or metastatic extra-axial tumor involving one or more anatomic structures in the head and neck * Vascular supply from one or more branches of the external carotid artery * Planned surgical resection * All stages * Extra-axial head and neck tumor greater than 1 cm in any dimension * Confirmed by contrast-enhanced magnetic resonance imaging (MRI) or computed tomography (CT) of the head and/or neck * Subjects who have undergone prior therapies are eligible * Adults aged 18-80; no data outside this age range * Minimum of 3-month life expectancy * Estimated glomerular filtration rate (eGFR) greater than 30 mL/min/1.73 m\^2 * Subjects must be non-pregnant at the time of angiographic intervention * Resectable tumor as determined by the Tumor Board * Medically stable at the time of the planned intervention, despite potential comorbidities * In English or Spanish. All study materials have been professionally translated into Spanish Exclusion Criteria: * Recent hemorrhage or trauma * Pregnancy * Nursing mothers * Contrast medium allergy * Hypersensitivity or known allergy to ethiodized oil, poppy seeds, or poppy seed oil * Uncontrolled or concurrent illness including ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Pregnancy is a contraindication to angiography outside of the emergency setting * Active thyroid disease may be affected by iodinated products * Subject is participating in another clinical trial at the enrollment of the study or duration of the study that can affect the treatment and outcome of the study