The Influence of Different At-home Exercise Strategies on 24h Glycemic Control

University of Toronto107 enrolled

Overview

This study will determine how different at-home exercise strategies influence 24hr glycemic control in women with metabolic dysfunction.

Elevations in blood glucose concentration increase risk for cardiometabolic diseases including type 2 diabetes and cardiovascular diseases. Exercise can improve glycemic control, but there is limited research comparing the effectiveness of different exercise strategies in women. The aim of this study is to examine, under free-living conditions, how performing either walking and bodyweight interval exercise after dinner influences glycemic control in women with or at risk for type 2 diabetes. Glycemic control will be measured with continuous glucose monitors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

107

Conditions

Metabolic Disturbance

Interventions

Bodyweight interval exerciseBEHAVIORAL

Performing 15 minutes of bodyweight interval exercise after dinner at home by following a video

WalkingBEHAVIORAL

Performing a 30 minute minute walk after dinner at home

Eligibility

Sex: FEMALEMin age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Females * no cancer history * ≥50 years old * Have metabolic dysfunction (defined as self-reported diagnosis of pre-diabetes, type 2 diabetes, or at least moderate Canadian diabetes risk (CANRISK) score) * Owns a smartphone with Bluetooth capability with Apple or Android operating system * deemed safe to exercise as per the CSEP Get Active Questionnaire * Enrolled in NCT05454943 Exclusion Criteria: * Type 1 diabetes * Taking exogenous insulin, sulfonylureas, or GLP-1 receptor agonists * Self-reported history of an eating disorder * BMI \<18.5 kg/m * Working night or rotating shifts * Eating window \<12 hours or consistently eating less than 3 meals/day in the past 3 months * Major dietary changes within the past 3 months (i.e. calorie counting, ketogenic diet)

Locations (1)

University of Toronto

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

24hr Glucose area under the curve

Glucose area under the curve over 24hr

Time frame: 24 hours

Secondary Outcomes

24hr Average glucose concentration

Average glucose concentration over 24 hr

Time frame: 24 hours

Postprandial dinner glucose response

Measured as the 2hr postprandial glucose incremental area under the curve (iAUC), average glucose and peak glucose

Time frame: 2 hours

Postprandial breakfast glucose response

Measured as the 2hr postprandial iAUC, average glucose and peak glucose

Time frame: 2 hours

Postprandial lunch glucose response

Measured as the 2hr postprandial glucose iAUC, average glucose and peak glucose

Time frame: 2 hours

Nocturnal glucose

Measured as the overnight glucose average and AUC

Time frame: ~6-8 hours

Time in hyperglycemia

Time (minutes and percent per day) above 10mmol/L over 24hr

Time frame: 24 hours

Time in hypoglycemia

Time (minutes and percent per day) under 3.9mmol/L over 24 hr

Time frame: 24 hours

Time in range

Data from ClinicalTrials.gov

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