Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study

Inclusion Criteria: 1. Age ≥18 2. Written informed consent and ability to understand the nature of the study and the study-related procedures and to comply with them 3. Histologically proven, resectable adenocarcinoma or squamous cell carcinoma of the esophagus or GEJ (gastroesophageal junction) according to the UICC TNM7 definition. Tumors of the esophagus and tumors of which the epicentre is within 5 cm of the GEJ are eligible for inclusion in the trial (Type 1 and Type 2 according to Siewert classification of esophagogastric adenocarcinoma 4. Pre-treatment stage cT2-4aN0-2M0 disease. In case of stage cT4a, the possibility for a curative resection has to be explicitly verified by the multidisciplinary tumor board 5. nCRT (CROSS regimen) completed, i.e. all radiotherapy fractions administered. 6. Complete clinical response 10-14 weeks after nCRT as determined by endoscopy with biopsies, EUS with FNA and PET/CT scanning 7. No prior cytotoxic chemotherapy other than as part of the neoadjuvant chemoradiation (CROSS) 8. Eastern Cooperative Oncology Group (ECOG) performance status 0-1. 9. Adequate cardiac function (cardiac function tests such as echocardiography only necessary in symptomatic patients). 10. Adequate respiratory function (pulmonary function tests only necessary in symptomatic patients). 11. Adequate bone marrow function (White Blood Cells \>2x10\^9/l; Haemoglobin \>6,2mmol/L; platelets \>100x10\^9/l). In the event of transfusions, the last red blood cell transfusion should be more than 2 weeks before inclusion. 12. Adequate renal function (Glomerular Filtration Rate \>40 ml/min) or Serum creatinine \<=1.5 x upper limit of normal (ULN) 13. Adequate liver function (AST and ALT \< 3.0 x ULN; Total bilirubin \< 1.5 x ULN (except participants with Gilbert Syndrome who may have a total bilirubin level of \< 3.0 x ULN) 14. Women of child-bearing potential must have a negative serum pregnancy test during screening period 15. Patients must be willing to use adequate contraception during the study and for 3 months after the end of the study. Exclusion Criteria: 1. Language difficulty, dementia or altered mental status prohibiting the understanding and giving of informed consent and to complete quality of life questionnaires; 2. Patients who were treated with definitive chemoradiotherapy 3. Patients who were unable to complete all radiotherapy fractions of the nCRT 4. No cCR at 10-14 weeks 5. Esophageal cancer evaluated as not curatively-resectable by the multidisciplinary tumour board, for instance because ingrowth in the trachea, aorta or vertebra (cT4b) 6. Gastric carcinoma 7. Clinically significant (active) cardiac disease (e.g. symptomatic coronary artery disease or myocardial infarction within last 12 months) 8. Clinically significant lung disease (Forced Expiratory Volume in one second (FEV1) 9. Pregnant and lactating women, or patients of reproductive potential who are not using effective birth control methods. If barrier contraceptives are used, they must be continued by both sexes throughout the study. 10. Participation, current or during the last 30 days prior to informed consent, in another intervention trial with interference to the chemotherapeutic or chemoradiotherapeutic intervention of this study. 11. Expected lack of compliance with the protocol 12. Refusal to undergo further active surveillance (i.e., opting for esophageal resection) 13. Prior malignancy active within the previous 2 years except for locally curable cancers that have been apparently cured or successfully resected, such as basal or squamous cell skin cancer, superficial bladder cancer, or GC, or carcinoma in situ of the prostate, cervix, or breast 14. Participants with an active, known or suspected autoimmune disease. Participants with type I diabetes mellitus, hypothyroidism only requiring hormone replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enrol. 15. Participants with a condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalents for adults, or \> 0.25 mg/kg daily prednisone equivalent for adolescent) or other immunosuppressive medications within 14 days of study treatment. Inhaled or topical steroids and adrenal replacement doses \> 10 mg daily prednisone equivalents for adults, or \> 0.25 mg/kg daily prednisone equivalent for adolescents are permitted, in the absence of active autoimmune disease. 16. Participants who received prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways 17. Anti-tumor treatment other than as part of neoadjuvant chemoradiation (CROSS) within 28 days of first administration of study treatment 18. Known history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS). 19. Any positive test result for hepatitis B virus or hepatitis C virus indicating presence of virus, e.g, hepatitis B surface antigen (HBsAg, Australia antigen) positive, or hepatitis C antibody (anti-HCV) positive (except if HCV-RNA negative) 20. Participants must not have received a live / attenuated vaccine within 30 days of first treatment. 21. History of severe hypersensitivity reactions to other monoclonal antibodies 22. History of allergy or hypersensitivity to study drug components