Informed decision-making regarding aneuploidy screening has been reported to be low. Poor knowledge and the lack of deliberation have been cited as reasons for uninformed choices, highlighting the need for adequate pre-test counselling. We conducted a study to assess if an educational video improves informed choice in a clinical setting where both the combined first trimester screen and non-invasive prenatal screening are offered routinely to pregnant women.
Women attending the antenatal clinic with a viable singleton pregnancy below 14 weeks were randomized to receive routine counselling by their obstetrician or the intervention, where they watched a 16-minute educational video on aneuploidy screening before their consult. The primary outcome, rate of informed choice, was assessed using an adapted multidimensional measure of informed choice (MMIC) questionnaire, where informed choice was defined as good knowledge and value-consistent behaviour. Secondary outcomes included informed choice with deliberation, decisional conflict and anxiety.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
286
See arm description
National University Hospital
Singapore, Singapore
Informed choice
Outcome will be measured using the modified multidimensional measure of informed choice (MMIC).
Time frame: Day 0
Deliberation
Outcome will be measured using 6 questions to measure deliberation on a five-point Likert scale
Time frame: Day 0
Knowledge
Outcome will be measured using a 19-item validated true/false knowledge questionnaire.
Time frame: Day 0
Value-consistent behaviour
Attitudes towards testing options were assessed using a validated questionnaire and deemed to be value consistent if a participants had a positive attitude towards the test option that they chose, or a negative attitude towards all test options and chose not to test.
Time frame: Day 0
anxiety
Anxiety was assessed using the Spielberger State trait anxiety inventory (STAI-6) short form which consisted of 6 items
Time frame: Day 0
Decisional Conflict
Decisional conflict was measured using a validated Decisional Conflict Scale (DCS)
Time frame: Day 0
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