Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
20
PS, OS, OS
OS, PS, OS
OS, OS, PS
University of Minnesota
Minneapolis, Minnesota, United States
RECRUITINGDifference in broadband power with different settings
Different settings include different combinations of stimulation amplitude, frequency and pulse width. The full spectrum PSD data from all of the in-clinic recordings at all of the unique settings will be combined to look at the resulting difference in broadband power.
Time frame: One year from baseline
Difference in frequency band-specific low-frequency power (LFP) with different settings
Different settings include different combinations of stimulation amplitude, frequency and pulse width. The full spectrum PSD data from all of the in-clinic recordings at all of the unique settings will be combined to look at the resulting difference in frequency band-specific LFP.
Time frame: One year from baseline
Identify all seizures
Detecting generalized tonic-clonic seizures using a wearable sensor wristband and patients-reported seizure activity.
Time frame: one year from baseline
Scores on Montreal Cognitive Assessment, MoCA
This is a brief cognitive assessment used to look at side effects of stimulation settings
Time frame: one year from baseline
Scores on epilepsy-specific quality of life questionnaire (QOLIE-10P)
This is a brief cognitive assessment used to look at side effects of stimulation settings
Time frame: One year from baseline
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.