This project is a prospective observational real-world study, recruiting and screening subjects who have completed 2 doses of the COVID-19 vaccine for more than 6 months and receive the third dose of the vaccine voluntarily into the clinical cohort of this study. Subjects received a third dose of the COVID-19 vaccine will be enrolled in the study and followed up for 1 year at baseline (day 0) before vaccine injection, 28 days after injection, 90 days, 270 days after injection. On the 365th day, blood samples were collected for the detection of anti-SARS-CoV-2 antibodies and other related indicators to evaluate the immune protection effect.
Study Type
OBSERVATIONAL
Enrollment
2,000
Completed 2 doses of an inactivated SARS-CoV-2 vaccine more than 6 months ago and received a third dose of the vaccine
Infectious department of Huashan Hospital, Fudan University
Shanghai, China
RECRUITINGGeometric mean titers (GMTs)
Geometric mean titers (GMTs) of serum COVID-19 neutralizing antibodies
Time frame: Day 28±3 after the third dose of vaccine injection
Geometric mean titers (GMTs)
Geometric mean titers (GMTs) of serum COVID-19 neutralizing antibodies
Time frame: Day 90±7, Day 180±7, Day 270±7, Day 365±7 after the third dose of vaccine injection
IgG
Serum SAS-CoV-2 IgG
Time frame: Day 28±3, Day 90±7, Day 180±7, Day 270±7, Day 365±7 after the third dose of vaccine injection
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