Comparing different advanced sperm selection techniques like Physiological ICSI (PICSI) and magnetic activated cell sorting (MACS) in terms of the PGT-A outcomes of each arm blastocysts
Advanced sperm selection methods like PICSI and MACS have been developed for selecting a healthy mature non apoptotic sperm with lower Sperm DNA fragmentation. Previous studies compared the pre-implantation embryo development parameters of those techniques, but none looked at comparing the PGT-A results or euploidy rates of the blastocysts derived from each sperm selection. PGT-A cases will be randomized on the day of ICSI to the 2 assigned sperm selection techniques.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
515
Ganin Fertility Center
Cairo, Maadi, Egypt
Euploidy rate
Defined as the proportion of euploid blastocysts
Time frame: 15 days post ICSI
Aneuploidy rate
Defined as the proportion of aneuploid blastocysts
Time frame: 15 days post ICSI
Low mosaic rate
Defined as the proportion of low mosaic blastocysts
Time frame: 15 days post ICSI
High mosaic rate
Defined as the proportion of high mosaic blastocysts
Time frame: 15 days post ICSI
Fertilization rate
Defined as the proportion of fertilizaed oocytes
Time frame: 1 day
Cleavage rate
Defined as the proportion of cleaved embryos on day 3
Time frame: 3 days
Blastocyst development rate
Defined as the proportion of blastocysts formed on day 5 or 6
Time frame: 5-6 days
Blastocyst quality rate
Defined as the assessment of blastocyst quality according to Gardner's criteria into: good, fair or poor
Time frame: 5-6 days
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