Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis

Karamanoğlu Mehmetbey University80 enrolled

Overview

The primary aim of this randomised control trial is to assess the impact of pre-operative carbohydrate loading on thiol disulfide homeostasis when compared to standard care in elective cesarean section. Half of the participants will receive pre-operative carbohydrates and the other half will receive standard care.

The concept of enhanced recovery after surgery (ERAS) has been gradually extended from surgery to the field of obstetrics. Carbohydrate loading before the surgery in obstetric patients reduce the incidence of nausea and vomiting and reduce insulin resistance. Although these effects of the preoperative carbohydrate loading has been studied, the thiol disulfide homeostasis effects after carbohydrate loading has not been investigated yet. Thiol-disulfide homeostasis (TDH) plays a critical role in the mechanisms of antioxidant defense, detoxification, apoptosis, regulation of enzyme activities, transcription, and cellular signal transduction. Since the newborns are very susceptible to harmfull effects of reactive oxygen species, the effect of carbohydrate loading on the reactive oxygen species gain importance. All mothers undergoing a planned caesarean section in the Karaman Training and Research Hospital will be invited to participate. Mothers will be divided into two groups. One group will receive standard care and the other group will receive a carbohydrate drink in addition to standard care.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Interventions

CarbohydrateDRUG

Preoperative Carbohydrate Loading Drink

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Term pregnancies, * Planned elective ceserean sections, * Under spinal anesthesia, * Pregnants who can read and write Turkish. Exclusion Criteria: * Preterm pregnants, * Pregnants with reflux, * obesity, * hiatus hernia, * ileus, * enteral nutrition, * alcohol or substance abuse, * prolonged delivery, * systemic chronic diseases, * malignancy, * GDM,eclampsia,preeclampsia, * fetal anomaliy, * prolonged delivery

Locations (1)

Karaman Training and Research Hospital

Karaman, Merkez, Turkey (Türkiye)

Outcomes

Primary Outcomes

The comparison of the changes in thiol disulfide values between the groups

The native thiol, total thiol, disulfide, native thiol/total thiol ratio, disulfide/native thiol ratio, and disulfide/total thiol ratio will be determined.

Time frame: From beginning to two hours after the surgery

Secondary Outcomes

Incidence of intraoperative hypotension

Hypotension is defined as a decrease in the mean arterial pressure by ˃20% of the baseline value.

Time frame: From beginning to the end of the surgery

Total ephedrine usage

At hypotensive episodes, 5 mg ephedrine will be used intravenously.

Time frame: From beginning to the end of the surgery

Data from ClinicalTrials.gov

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