Comparing P1101 to Entecavir in Patients With HBeAg(-) Hepatitis B Under Long-term Nucleos(t)Ide Analogue Therapy

Inclusion Criteria: * Adults with age 20-75 years old; Subjects who are over 70 years of age must be in generally good health; * Confirmed diagnosis of chronic hepatitis B (CHB) virus infection: with positive HBsAg ≧ 6 months prior to the study entry; * Quantitative HBsAg level \< 1,500 IU/ml at screening; * Confirmed HBeAg (-) at screening; * Stable disease: ALT \< 3 x upper limit of normal (ULN), total bilirubin \< 1.5 × ULN (except in Gilbert syndrome) and direct bilirubin \< ULN at screening, serum HBV DNA \< 50 IU/mL for ≧ 1 year prior to study entry; * Stable treatment with nucleos(t)ide regimen (adefovir, entecavir, tenofovir or one of the following combinations: entecavir/adefovir or entecavir/tenofovir) for at least 2 years prior to study entry; * Interferon treatment naïve; * Normal fundoscopic examination by ophthalmologist at screening; defined as no significant or major fundoscopic findings including but not limited to retinal exudates, hemorrhage, detachment, neovascularization, papilloedema, optic atrophy, microaneurysms and macular changes; * Be able to attend all scheduled visits and to comply with all study procedures; * Be able to provide written informed consent. Exclusion Criteria: * HBeAg-positive chronic hepatitis B; * Documented history of drug resistance to any nucleoside/ nucleotide analogue; * History of treatment with lamivudine or telbivudine prior to the study entry; * Clinically significant abnormalities, other than HBV infection, based upon the results of a medical history, physical examination, vital signs, and a 12-lead electrocardiogram (ECG) at screening as determined by the investigator; * Other form of significant chronic liver disease apart from chronic hepatitis B infection; Severe steatohepatitis by ultrasound or other examinations at the discretion of investigators; * Liver cirrhosis; * Known positive for anti-HIV; * Positive for anti-hepatitis C virus(HCV), Subject could be enrolled if no HCV RNA detected within 1 year； * Co-infection with hepatitis D; * One of clinically significant abnormal laboratory test result at screening: white blood cell (WBC) \< 3,000/mm\^3, absolute neutrophil count (ANC) \< 1500/mm\^3, Hgb \< 10g/dL, platelet \< 90,000/mm\^3, estimated Glomerular filtration rate \< 60 mL/min; * History of significant alcohol or illicit drug abuse within six months prior to the screening visit (alcohol consumption of more than fourteen units of alcohol per week \[1 Unit = 150 mL of wine, 360 mL of beer, or 45 mL of 40% alcohol\]) or refusal to abstain from illicit drugs and minimize alcohol consumption throughout the study; * History of severe allergic or hypersensitivity reactions (e.g bronchospasm, angioedema), asthma, or anaphylaxis * Therapy with any systemic anti-viral treatment (except for treatment for HBV), anti-neoplastic, immunomodulatory treatment (including supraphysiologic doses of steroids and radiation) and immunosuppressants within 1 month (3 months for those with long elimination half-lives) prior to the first dose of study drug; * Use of an investigational drug within the last 4 weeks; * Any history or presence of poorly controlled or clinically significant medical conditions that are not suitable to receive interferon-based treatment, at the discretion of the investigator: major psychiatric (including but not limited to those with severe depression, severe bipolar disorder, schizophrenia, suicidal ideation or history of suicidal attempt),neurological, cardiovascular (e.g. uncontrolled hypertension), pulmonary (including but not limited to chronic obstructive lung disease), hematological, immunologic, endocrine, metabolic (e.g. diabetes mellitus with HbA1C \> 8.0%), autoimmune disease, thyroid or other uncontrolled systemic disease, coagulation disorders or blood dyscrasias; * A depot injection or an implant of any drug within 3 months prior to administration of study medication, other than contraception or hyaluronic acid injections in joints for osteoarthritis; * History of solid organ transplantation; * History of malignancy diagnosed or treated within 5 years prior to screening (except for recent localized treatment of squamous or noninvasive basal cell skin cancers; cervical carcinoma in situ), cancer survivors not on maintenance therapy within the past 5 years; * History of opportunistic infection (e.g., invasive candidiasis or pneumocystis pneumonia) * Serious localized infection (e.g., cellulitis, abscess) or systemic and life-threatening infection (e.g., septicemia) within the 3 months prior to screening; * Pregnant subjects. Female subjects or the spouse of male subjects, with child-bearing potential who are unwilling or unable to practice adequate contraception, defined as vasectomy in men, tubal ligation in women, or use of condoms and spermicides, or birth control pills, or intrauterine devices from 4 weeks prior to Day 1 until 90 days after the last dose of study drug.