This study evaluated the effectiveness and safety of improving Mild Dementia by applying tDCS for 26 weeks to patients with Mild Dementia.
Patients received tDCS for 30 minutes with an intensity of 1.5 to 2 mA. tDCS was applied over the left (anode) and right (cathode) dorsolateral prefrontal cortex (DLPFC) 5\~7 times a week and they were evaluated every 26weeks through questionnaires.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
118
transcranial Direct Current Stimulation (tDCS) 2mA for 30 min; 30 sec of ramp-up and -down; left (anode) and right (cathode) Dorsolateral prefrontal cortex (DLPFC)
Sham stimulation; only 30 sec of ramp-up and -down; left (anode) and right (cathode) Dorsolateral prefrontal cortex (DLPFC)
The Catholic University of Korea at incheon
Incheon, South Korea
RECRUITINGKorea University
Seoul, South Korea
RECRUITINGChanges in K-MMSE (Mini Mental State Examination)
Changes in K-MMSE after 26 weeks form pretreatment (min value : 0 / max value: 30 / Higher scores mean a better outcome)
Time frame: After 26 weeks after treatment
Changes in K-IADL(Korean-Isturemental Activities of Daily Living)
Changes in K-IADL after 26 weeks from pretreatment (min value : 0 / max value: 33 / Higher scores mean a worse outcome)
Time frame: After 26 weeks after treatment
Changes in CDR(Clinical Dementia rating)
Changes in CDR after 26 weeks from pretreatment (min value : 0 / max value: 3 / Higher scores mean a worse outcome)
Time frame: After 26 weeks after treatment
Changes in MoCA-K (Korean version of Montreal Cognitive Assessment)
Changes in MoCA-K after 26 weeks from pretreatment (min value : 0 / max value: 30 / Higher scores mean a better outcome)
Time frame: After 26 weeks after treatment
Changes in NPI (Neuropsychiatric Inventory)
Changes in NPI after 26 weeks from pretreatment (min value : 0 / max value: 144 / Higher scores mean a worse outcome)
Time frame: After 26 weeks after treatment
Changes in QoL-AD(Quality of life-ADL-AD)
Changes in QoL-AD after 26 weeks from pretreatment (min value : 13 / max value: 52 / Higher scores mean a better outcome)
Time frame: After 26 weeks after treatment
Changes in FQoL-AD (Family's Quality of life-ADL-AD)
Changes in FQoL-AD after 26 weeks from pretreatment (min value : 13 / max value: 52 / Higher scores mean a better outcome)
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Time frame: After 26 weeks after treatment
Changes in ADAS-Cog 11 (Alzheimer's Disease Assessment Scale-Cog 11)
Changes in ADAS-Cog 11 after 26 weeks from pretreatment (min value : 0 / max value: 70 / Higher scores mean a worse outcome)
Time frame: After 26 weeks after treatment