The aim of this work to study the hemodynamic changes accompanying anemia of prematurity in neonates with gestational age ≤32 weeks and the effect of its treatment on hemodynamics.
This prospective observational study aims to evaluate the hemodynamic changes provoked by anemia of prematurity and transfusion of packed red blood cells (RBCs). Nonanemic inpatient premature infants (Hematocrit\>30%) will be compared with pretransfusional anemic inpatient premature infants. Anemic premature infants will be assessed before and 24 hours after the transfusion of pRBCs. Cerebral, intestinal and renal blood flow velocities, cardiac output parameters will be measured in premature neonates who will fulfill the eligibility criteria of the study.This study will be conducted at the neonatal intensive care units in Alexandria University Hospitals.
Study Type
OBSERVATIONAL
Enrollment
72
Echographic and Doppler studies will be performed using machine: model GE Vivid iq premium,WUXI,China and we will measure: 1. Cardiac output: 2. Cerebral, intestinal and renal blood flow velocities:
Neonatal Intensive Care Unit (NICU) of Alexandria University Maternity Hospital.
Alexandria, Egypt
1. Cardiac output:
Probe: GE 12S-RS probe with a frequency range of 5 - 11 MHz. Cardiac output as the product of stroke volume and heart rate: actual body weight in mL/kg/min; Stroke volume (the product of velocity time integral at the level of aortic valve pulsed wave (PW) and cross-sectional area of the left ventricular outflow tract at the level of aortic valve using 2D.(
Time frame: 3-6 weeks postnatal age
2. Cerebral blood flow velocities
in the anterior cerebral artery through the anterior fontanelle in the sagittal plane
Time frame: 3-6 weeks postnatal age
3. Intestinal blood flow velocities
in the celiac artery from a longitudinal abdominal section, determined close to the origin of the artery from the abdominal aorta.
Time frame: 3-6 weeks postnatal age
4.Renal blood flow velocities
Renal blood flow velocities in the right renal artery by placing the transducer below the right costal arch in the dorsolateral area of the flank in longitudinal axis.
Time frame: 3-6 weeks postnatal age
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