Effects of Rifampicin and Probenecid On The Pharmacokinetic Profile Of Rongliflozin In Healthy Subjects

Inclusion Criteria: * Sign the informed consent form before the trial and fully understand the trial content, process and possible adverse reactions; * Be able to complete the test according to the requirements of the protocol; * Subjects (including partners) are willing to take effective contraceptive measures from screening to 6 months after the last dose of drug administration; * Male subjects weigh at least 50 kg and female subjects at least 45 kg. Body mass index (BMI) = weight (kg)/height 2 (m2), BMI within the range of 18 to 28 kg/m2 ; * Physical examination and vital signs are both normal or do not have clinical significance. Exclusion Criteria: * Smoking more than 5 cigarettes per day; * Those who are allergic to or have allergies to the test drug; * have a history of drug or alcohol abuse; * Blood donation or massive blood loss (\>450 mL) within three months prior to screening; * Difficulty swallowing or any history of digestive system diseases which could affect drug absorption and excretion within 6 months before screening; * taking any drugs that could alter liver enzyme activity, such as barbiturates, rifampin, etc., within 30 days before screening; * have taken any prescription, over-the-counter, vitamin product or herbal medicine within 14 days prior to screening; * Have taken special diets (including dragon fruit, mango, grapefruit, etc.) or exercised strenuously within 2 weeks before screening; * Take an inhibitor or inducer of glucuronide transferase (UGT), P-glycoprotein (P-gp) or breast cancer resistance protein (BCRP), such as itraconazole, ketoconazole, or dronedarone, within 30 days before screening; * Significant changes in dietary or exercise habits within 2 weeks prior to screening; Female subjects are breastfeeding or have a positive blood pregnancy result during the screening period; * During the screening period, the serum uric acid level was \>420 µmol/l, or had a history of gout; during the screening period, the estimated glomerular filtration rate (eGFR) was \<90 ml/min/1.73m2) or had a history of kidney stones or bladder stones (applicable to Cohort B); * have a clinically significant laboratory tests or medical history; * Positive for hepatitis B, hepatitis C, AIDS, syphilis; positive for urine drug test; * History of urinary tract infection or genital infection before 6 months * Those who participated in any drug clinical trial and used the experimental drug 3 months ago; * Subjects with other factors deemed inappropriate by the investigator.