The Acute Effect of Low-carb Diet on the Plasma Fatty Acid Composition in Type 2 Diabetes

Inclusion Criteria: 1. Duration of established type 2 diabetes for more than six months and less than five years, but duration of type 2 diabetes for up to 10 years if the current treatment consists of ≤ 2 oral antidiabetic drugs without insulin. 2. HbA1c in compliance with type 2 diabetes (above 48 mmol/mol), with or without use of glucose-lowering pharmacotherapy, but without need for adjustment of antidiabetic treatment. 3. Stable antidiabetic treatment three months prior to inclusion. 4. Well treated dyslipidemia (LDL cholesterol \< 2.5 mmol/l and total cholesterol \< 4.5 mmol/l at inclusion) with or without statins. 5. BMI ≥ 25. 6. Age ≥ 18 years. 7. All participants have to understand oral and written Danish. 8. All participants have to sign an informed consent after oral and written information on experimental design. Exclusion Criteria: 1. Significant comorbidity, including liver disease. 2. A history of cancer \< 5 years or current chemotherapy. 3. Other severe co-morbidity that could interfere with study compliance or safety (e.g. previous gastrointestinal operations, liver disease, history of eating disorder, current alcohol overuse or hypoglycemic unawareness). 4. Current treatment with glucocorticoids (systemic). 5. Continuous treatment with steatosis-inducing drugs. 6. Treatment with antibiotics during the last two months before inclusion. 7. Low-carbohydrate diet prior to inclusion, or other restrictive diet. 8. Weight-loss \> 10 kg over the last three months before inclusion. 9. Pregnancy or expected pregnancy within the next 6 months. 10. Elevated blood pressure (180/110) with or without antihypertensives.