Prolonged Cardiopulmonary Bypass Time as a Predictive Factor for AGI After Heart Valve Replacement

Hepatopancreatobiliary Surgery Institute of Gansu Province1,070 enrolled

Overview

In this retrospective study, the investigators will analyze the correlation between cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes of AGI in patients undergoing heart valve replacement.

Patients with heart valve diseases often have chronic cardiac insufficiency. Patients undergoing heart valve replacement with CPB are always complicated with gastrointestinal tract ischemia-reperfusion injury, which usually leads to AGI. AGI after cardiovascular surgery, especially in that use CPB, is associated with significant morbidity and an increase in peri-operative mortality. Prolonged CPB time could be predictive of AGI following heart valve replacement. This study is to analyze the correlation between CPB time and AGI, and the outcomes of AGI in patients undergoing heart valve replacement. The investigators hope that the benefits will include fewer patients becoming seriously postoperative AGI and mortality after cardiac surgery.

Study Type

OBSERVATIONAL

Enrollment

1,070

Conditions

Heart Valve Diseases

Interventions

CPB timeOTHER

Cardiopulmonary bypass time

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing heart valve replacement surgery with CPB * Age \> 18 years and ≤ 70 years Exclusion Criteria: * Patients combined with severe hematological disease, respiratory disease, and other critical diseases * Patients had severe disorder of multiple systems and organs or severe pulmonary hypertension * Have received major gastrointestinal surgery within 5 years * Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis * Acute gastroenteritis * Clostridium difficile or Helicobacter pylori infection * Chronic constipation * Peptic ulcer * Polyps in the stomach or intestines * Gastrointestinal neoplasms * Abdominal hernia * Irritable bowel syndrome * Acute or chronic cholecystitis, hepatitis * Patients who died during surgery * Patients with digestive system tumors

Locations (1)

Hepatopancreatobiliary Surgery Institute of Gansu Province

Lanzhou, Gansu, China

Outcomes

Primary Outcomes

Cardiopulmonary bypass (CPB) time

Was defined it as the sum of times of CPB during surgery (minutes).

Time frame: 1 month

The AGI score

The AGI score of the patient within the seventh postoperative day was performed according to the European Society of critical care (2012) guidelines for AGI.

Time frame: 1 month

Secondary Outcomes

Number of bowel sounds

The return time of bowel sounds was evaluated morning and evening.

Time frame: 1 month

First defecation time

The time to the first defecation was asked morning and evening after surgery

Time frame: 1 month

Proportion of cocci and bacilli in feces

The first feces were collected in sterile containers for the bacterial smear

Time frame: 1 month

Alanine aminotransferase (ALT)

We defined it as the maximum value of ALT within 7 days after surgery.

Time frame: 1 month

Aspartate aminotransferase (AST)

We defined it as the maximum value of AST within 7 days after surgery

Time frame: 1 month

Left ventricular ejection fraction (LVEF)

We measured the LVEF on the 1st and 3rd days after operation by echocardiographic examinations

Time frame: 1 month

Data from ClinicalTrials.gov

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