Acute myocardial inflammation is an heterogenic syndrome involving different clinical pathologies with different outcome. For the purpose of this study protocol, we focuse on three entities of this syndrome, namely the acute cellular cardiac allograft rejection (ACR), cardiac sarcoidosis (CS) and the immune checkpoint inhibitor induced myocarditis (ICIM), for which non-invasive diagnosis remains challenging. Since accurate diagnosis of myocardial inflammation in an early stage is crucial, this study aims to investigate the accuracy of \[68Ga\]Ga-PentixaFor as a marker of for the presence of inflammatory cells (T-lymphocytes and M1) in described patients. The identification of a correlation between \[68Ga\]Ga-PentixaFor myocardial accumulation with currently accepted diagnostic tools would open up new ways to non-invasively diagnose acute myocardial inflammation.
Imaging will consist of administration of maximum 50 µg IV PentixaFor, labelled with 150 ±15 MBq of 68Ga, as bolus injection 60 ±15 minutes prior PET/CT
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
69
\[68Ga\]Ga-PentixaFor PET/CT
Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland
RECRUITINGImaging results obtained by [68Ga]Ga-PentixaFor PET/CT - lesion number
lesion number imaged
Time frame: 1 year
Imaging results obtained by [68Ga]Ga-PentixaFor PET/CT - lesion site
lesion sites imaged
Time frame: 1 year
Imaging results obtained by [68Ga]Ga-PentixaFor PET/CT - SUV
standard uptake value
Time frame: 1 year
to assess toxicity data
analysis of collected AEs classified according to CTCAE version 5.0
Time frame: 1 year
Christel Kamani, MD
CONTACT
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