Relevance of Sarcopenia in Advanced Liver Disease

Linkoeping University150 enrolled

Overview

Patients with established liver cirrhosis, or end-stage liver disease (ESLD), are at high risk of developing liver cancer (hepatic carcinoma; HCC), portal hypertension, and sarcopenia, all which lead to significant morbidity and mortality. In this patient group the annual incidence of HCC is c. 2-8% and these patients are therefore included in ultrasound HCC screening programs every 6 months. In this study, the investigators are aiming to assess sarcopenia, clinically significant portal hypertension (CSPH), and HCC with a single short magnetic resonance (MR) examination. A neck-to-knee MRI-examination will be acquired to derive body composition profile (BCP) measurements including visceral and abdominal subcutaneous adipose tissue (VAT and ASAT), thigh fat free muscle volume (FFMV) and muscle fat infiltration (MFI), as well as liver fat (PDFF), spleen volume, and liver stiffness. Images will be further processed by AMRA Medical AB. AMRA's solution includes FFMV in the context of virtual control groups (VCG; using AMRA's vast database) and MFI. Furthermore, the spleen volume will be used to monitor the development of portal hypertension and explored together with other BCP variables in relation to hepatic decompensation events. HCC screening will be performed using so-called abbreviated MRI (AMRI), which consists of time series of contrast-enhanced T1-weighted images. The AMRI images will be read by an experienced radiologist. In the literature the sensitivity of AMRI to detect HCC is above 80%, with a specificity of c. 95%, compared to ultrasound sensitivity of 60%. In treating ESLD there is a desire of physicians to be able to predict future decompensation events in order to initiate treatment to prolong survival. Moreover, the ability to assess processes of sarcopenia in the patient would be highly valuable for clinical practice due its severe clinical impact. Finally, ultrasound-based HCC screening has poor diagnostic performance and a MR-based screening approach would significantly improve treatment outcome as more treatable and earlier HCC may be identified.

150 patients with established or probable liver cirrhosis at the Department of Gastroenterology and Hepatology at Linköping University Hospital, as well as collaborating hospitals; District Hospital in Eksjö and County Hospital in Jönköping, will be included in the study. The study includes four visits every six months (in patients with LI-RADS 3 five visits will be performed); each patient participates actively in the study during a time period of approximately 24 months. All study visits are scheduled in conjunction with clinical routine visits. During each study visit the following is performed: * A detailed clinical work-up * Assessment of medical history or changes in health status since last visit * FibroScan * Magnetic resonance (MR) examination * Comprehensive blood panels and blood samples for research * Muscle function and mobility assessments (SPPB and hand grip strength). * Quality of life assessment (EQ-5D-5L, QLDQ-cirrhosis and SHS-liver). * Hepatic encephalopathy assessment (ANT test). * Assessment of the development of symptoms

Outcomes

Primary Outcomes

Body composition (FFMVvcg)

FFMVvcg is the thigh fat-free muscle volume in the context of virtual controls which effectively measures the deviation from expected thigh fat-free muscle volume normalized to height squared using sex and BMI matched virtual control groups.

Time frame: Baseline

Body composition (FFMVvcg)

Time frame: 6 months

Body composition (FFMVvcg)

Time frame: 1 year

Body composition (FFMVvcg)

Time frame: 18 months

Change from baseline Body composition (FFMVvcg)

Time frame: 6 months

Change from 6 months Body composition (FFMVvcg)

Time frame: 1 year

Change from 1 year Body composition (FFMVvcg)

Time frame: 18 months

Muscle fat infiltration (%) [MFI]