Occludin and Zonulin in Attention-deficit/Hyperactivity Disorder

Ataturk University79 enrolled

Overview

The association between levels of zonulin and occludin and behavioral/emotional problems in children with ADHD are investigated.

Inclusion criteria for the ADHD group are (a) newly diagnosed ADHD (b) no prior psychotropic treatment for ADHD or any psychiatric disorder (c) age 6-12 years. Exclusion criteria were: (a) history of history of inflammatory/noninflammatory, metabolic, or autoimmune disease (b) any special diet history within the past year (c) use of corticosteroids or regular intake of medication in the last 6 months, (d) body mass index (BMI) \[kg/m2\] \> 30), and (e) cognitive deficits by developmental history.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Attention-deficit/Hyperactivity Disorder

Interventions

ZonulinDIAGNOSTIC_TEST

Serum zonulin level

OccludinDIAGNOSTIC_TEST

Serum occludin level

Eligibility

Sex: ALLMin age: 6 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * (a) newly diagnosed ADHD * (b) no prior psychotropic treatment for ADHD or any psychiatric disorder * (c) age 6-12 years. Exclusion Criteria: * (a) history of history of inflammatory/noninflammatory, metabolic, or autoimmune disease * (b) any special diet history within the past year * (c) use of corticosteroids or regular intake of medication in the last 6 months, * (d) body mass index (BMI) \[kg/m2\] \> 30), * (e) cognitive deficits by developmental history

Locations (1)

Ataturk University Hospital

Erzurum, Turkey (Türkiye)

Outcomes

Primary Outcomes

Zonulin level

Serum Zonulin level after psychiatric interview

Time frame: 1 month

Occludin level

Serum Occludin level after psychiatric interview

Time frame: 1 month

Data from ClinicalTrials.gov

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