Safety and Pharmacokinetic Study of NPT 2042 Soft-gelatin Capsules Administered Orally to Healthy Adult Subjects

Inclusion Criteria: 1. Body mass index (BMI) of 18 to 32 kg/m2, inclusive 2. A minimum body weight of 50 kg for males and 45 kg for females 3. All females must have a negative serum pregnancy test at Screening and a negative serum pregnancy test upon admission to the clinical research center. 4. Females must be of nonchild-bearing potential defined as permanently sterile (i.e., due to hysterectomy) or postmenopausal (defined as more than one year since last menstrual period). 5. Male subjects with female partners of reproductive potential must agree to practice abstinence or to use a condom (male subjects) plus an additional barrier method (female partner) of contraception for the duration of the study and for at least 90 days after dosing; subjects must also agree to refrain from sperm donation for at least 90 days after their last dose of IP. 6. Able to swallow capsules. Exclusion Criteria: 1. Presence of active or recurring clinically-significant cardiovascular, pulmonary, renal, endocrine, hepatic, neurologic, psychiatric, immunologic, hematologic, gastrointestinal, or metabolic disease requiring medical treatment. 2. Presence of an active malignancy or a malignancy of any type within the past five years, other than squamous cell or basal cell carcinoma of the skin. 3. Personal or family history of long QT syndrome. 4. History or evidence of adverse symptoms associated with phlebotomy or blood donation (e.g., prolonged bleeding after injury or shaving, frequent epistaxis or gingival bleeding, bruises easily). 5. History of clinically significant vertigo, dizziness or orthostatic hypotension or any vasovagal syncope or recurrent presyncope in connection with orthostatic challenge. 6. Reported use of or inability to refrain from or anticipated use of during the study * any prescription drug within 14 days prior to dosing; * any nonprescription drug, nutritional supplement, or vitamin within 7 days prior to dosing; NOTE: acetaminophen is allowed at a dose of ≤2000 mg/day * any known enzyme-inducer or enzyme-inhibitor including St. John's Wort within 28 days prior to dosing, or * reported chronic exposure to enzyme inducers such as paint solvents or pesticides within 30 days of dosing. 7. Supine blood pressure (BP) less than 80/50 mmHg or greater than 140/90 mmHg. 8. Supine heart rate \<40 bpm and \>90 bpm. 9. History of drug abuse or current use of drugs of abuse or excessive ethanol intake 10. Current Smoking, vaping, hookah, chewing tobacco, or history of smoking/vaping/chewing any substance 11. Average consumption of ≥3 caffeine-containing beverages or xanthine-containing foods per day. 12. Positive urine drug, alcohol, or cotinine result at screening