Zanubrutinib-rituximab(ZR) in Patients With Newly Diagnosed Untreated Mantle Cell Lymphoma

Inclusion Criteria: 1. Histopathologically or Cytologically confirmed Mantle Cell Lymphoma(excluding indolent Mantle Cell Lymphoma) by the 2008 World Health Organization (WHO) Classification of diseases; 2. Initial untreated patients; 3. Age ≥ 18 years; 4. ECOG score 0-2; 5. Women must not be pregnant or breastfeeding and agree to avoid pregnancy prior to study entry, for the duration of study participation, and for 12 months thereafter. Male patients must agree that their spouses will not become pregnant during the study period and for 12 months thereafter; 6. Patients must have measurable disease (i.e., ≥ 1.0 cm in lymph nodes diameter; or skin lesions assessed by physical examination); 7. Written informed consent obtained from the subject. Exclusion Criteria: 1. Indolent Mantle Cell Lymphoma; 2. Patients with severe liver and kidney dysfunction (alanine aminotransferase, bilirubin, creatinine \> 3 times the upper limit of normal) 3. Uncontrolled active infection, with the exception of tumor-related B symptom fever; 4. Patients with organic heart disease with clinical symptoms or cardiac dysfunction (NYHA grade ≥2); 5. Co-existence of other tumors; 6. Any other psychological conditions that prevent patients from participating in the study or signing the informed consent form.