High flow nasal cannula (HFNC) is used in interventional procedures to prevent hypoxia during sedation. In patients with a patent airway, HFNC reduces dead space ventilation as well. It is unknown if dead space ventilation is also reduced by HFNC in an EndoBroncheal UltraSound procedure, in which the airway is partially blocked by the endoscope. Especially in patients with Chronic Obstructive Pulmonary Disease (COPD) the partial blocking of the airway may reduce ventilation. If HFNC is able to reduce dead space during an EBUS-procedure, it may facilitate CO2 clearance, which may lead to a reduction in work of breathing. This study aims to investigate if HFNC reduces dead space ventilation in patients undergoing an EBUS-procedure and if this is flow-dependent. A randomized, double-blinded, cross-over study is designed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
20
2 different rates of nasal flow compared to each other and a baseline of level of nasal oxygen
Rijnstate Hospital
Arnhem, Netherlands
Inspiratory CO2 at 10 minutes (baseline)
Inspiratory CO2, measured at the carinal level
Time frame: at t=10 minutes
Inspiratory CO2 at 25 minutes
Inspiratory CO2, measured at the carinal level
Time frame: at=25 minutes
Inspiratory CO2 at 45 minutes
Inspiratory CO2, measured at the carinal level
Time frame: at t=45 minutes
expiratory CO2 at 10 minutes (baseline)
Expiratory CO2, measured at the carinal level
Time frame: at t=10 minutes
expiratory CO2 at 25 minutes
Expiratory CO2, measured at the carinal level
Time frame: at t=25 minutes
expiratory CO2 at 45 minutes
Expiratory CO2, measured at the carinal level
Time frame: t=45 minutes
Slope of capnography at 10 minutes (baseline)
Angle of the D-E segment (inspiratory slope)
Time frame: At t=10 minutes
Slope of capnography at 25 minutes
Angle of the D-E segment (inspiratory slope)
Time frame: At t=25 minutes
Slope of capnography at 45 minutes
Angle of the D-E segment (inspiratory slope)
Time frame: At t=45 minutes
Respiratory rate
Respiratory rate, measured by capnography
Time frame: At t=10 minutes
Respiratory rate
Respiratory rate, measured by capnography
Time frame: At t=25 minutes
Respiratory rate
Respiratory rate, measured by capnography
Time frame: At t=45 minutes
The level of HFNC dead space washout
Levels of inspiratory and expiratory CO2 measured at the level of the left main bronchus, level of carina and the subglottic level.
Time frame: At t=10 minutes
The level of HFNC dead space washout
Levels of inspiratory and expiratory CO2 measured at the level of the left main bronchus, level of carina and the subglottic level.
Time frame: At t=25 minutes
The level of HFNC dead space washout
Levels of inspiratory and expiratory CO2 measured at the level of the left main bronchus, level of carina and the subglottic level.
Time frame: At t=45 minutes
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