Time-restricted Eating and Interval Training With Digital Follow-up

Norwegian University of Science and Technology52 enrolled

Overview

This study will investigate the effects of seven weeks of time-restricted eating combined with high-intensity interval training compared with a control group on body composition in adults with overweight/obesity. Participants in the intervention group will complete the intervention remotely and will receive weekly follow-up through online platforms (telephone, video call). Before and after the intervention, the investigators will measure the participants' body composition, physical fitness, fasting blood glucose and insulin, blood lipids, and blood pressure. Physical activity, diet, sleep quality, appetite, and adherence to the intervention will also be measured. Secondary sub-analyses of sex differences in the responses to the intervention will be performed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Overweight and Obesity

Interventions

Maximal daily eating window of 10 hours and high-intensity interval training (three weekly, unsupervised, aerobic exercise sessions performed at \> 90 % heart rate maximum). Each exercise session will last for 33-38 minutes. Participants will receive digital follow-up once weekly. The intervention period will be seven weeks,

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Body mass index ≥ 27 kg/m² * Able to walk or ride a bike \> 60 min Exclusion Criteria: * On-going pregnancy * Lactation within 24 weeks of study commencement * High-intensity exercise ≥ 1/week * Habitual eating window ≤12 hours/day * Taking hypertension, glucose-, or lipid-lowering drugs * Body mass variation ≥ 4 kg three months prior to study commencement * Known diabetes mellitus (type 1 or 2) or cardiovascular disease * Working night shifts

Outcomes

Primary Outcomes

Total fat mass

Change in total fat mass measured with bioelectrical impedance analysis

Time frame: From baseline to after 7 weeks of intervention

Secondary Outcomes

Blood glucose

Fasting concentration of plasma glucose

Time frame: From baseline to after 7 weeks of intervention

Insulin

Fasting concentration of plasma insulin C-peptide

Time frame: From baseline to after 7 weeks of intervention

Average glucose levels

Glycated hemoglobin (HbA1c)

Time frame: From baseline to after 7 weeks of intervention

Blood Cholesterol

Total fasting cholesterol in blood

Time frame: From baseline to after 7 weeks of intervention

HDL-cholesterol in blood

Fasting high-density lipoprotein-cholesterol in blood

Time frame: From baseline to after 7 weeks of intervention

LDL-cholesterol in blood

Fasting low-density lipoprotein-cholesterol in blood

Time frame: From baseline to after 7 weeks of intervention

Triglycerides in blood

Fasting triglycerides in blood

Time frame: From baseline to after 7 weeks of intervention

Insulin sensitivity

Homeostatic model assessment for insulin resistance (HOMA-IR): 1.5 + fasting plasma glucose (mmol/L) × fasting plasma insulin C-peptide (pmol/L) / 2800

Time frame: From baseline to after 7 weeks of intervention

Cardiorespiratory fitness

Peak oxygen uptake at a maximum effort exercise test, measured in mL/min/kg and L/min

Time frame: From baseline to after 7 weeks of intervention

Body mass

In kg, estimated with bioelectrical impedance analysis

Time frame: From baseline to after 7 weeks of intervention

Body fat-free mass

In kg, estimated with bioelectrical impedance analysis

Time frame: From baseline to after 7 weeks of intervention

Visceral fat area

In cm², estimated with bioelectrical impedance analysis

Time frame: From baseline to after 7 weeks of intervention

Systolic blood pressure

Average of three measurements during rest in seated position, in mmHg

Time frame: From baseline to after 7 weeks of intervention

Diastolic blood pressure

Average of three measurements during rest in seated position, in mmHg

Time frame: From baseline to after 7 weeks of intervention

Resting heart rate

Average of three measurements during rest in sitting position, in beats/min

Time frame: From baseline to after 7 weeks of intervention

Physical activity level

International Physical Activity Questionnaire, categorical score

Time frame: From baseline to after 7 weeks of intervention

Self-reported physical activity

Self-reported duration and intensity of daily physical activity during baseline week, first week of intervention, and last week of intervention, in metabolic equivalent of task (MET)/week

Time frame: 7 days at baseline, 7 days at start of intervention, 7 days at end of intervention.

Diet intake

Online food diary during baseline week, first week of intervention, and last week of intervention, in kilojoules (kJ)/week

Time frame: 7 days at baseline, 7 days at start of intervention, 7 days at end of intervention.

Sleep quality

The Pittsburgh Sleep Quality Index questionnaire

Time frame: From baseline to after 7 weeks of intervention

Sleep duration

Self-reported hours of sleep per night during baseline week, first week of intervention, and last week of intervention, average hours/night

Time frame: 7 days at baseline, 7 days at start of intervention, 7 days at end of intervention

Appetite

Self-reported ratings of hunger/satiety on visual analogue scale upon waking and before bedtime during baseline week, first week of intervention, and last week of intervention, average hours/night

Time frame: 7 days at baseline, 7 days at start of intervention, 7 days at end of intervention

Time-restricted Eating and Interval Training With Digital Follow-up

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes