This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome. Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.
Study Type
OBSERVATIONAL
Enrollment
459
Blood HbA1c, insulin, C-peptide and IL-6 measured at admission. Glucose and lactate measured every 4 hours during intensive care stay. Daily sampling of CSV analysed for glucose and lactate in patients with EVD.
Department of Neuroanesthesiology and Neurointensive Care, Rigshospitalet
Copenhagen, Denmark
Functional outcome at 6 months as evaluated by the modified Rankin Scale.
Modified Rankin Scale ranges from 0-6, where 0 is the best and 6 is the worst outcome.
Time frame: 6 months after admission.
All-cause mortality at 6 months (dichotomous).
Time frame: 6 months after admission.
Length of stay in the neuro-ICU (continuous).
Time frame: Day of discharge, typically 1-30 days after admission.
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