The primary objective of the study is to evaluate the safety and tolerability of REGN14284 in healthy participants, as measured by all treatment-emergent adverse events (TEAEs) and treatment-emergent serious adverse events (SAEs). The secondary objectives of the study are: * To assess the concentration-time profile of REGN14284 in serum * To assess the immunogenicity of REGN14284
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
48
Single ascending intravenous (IV) or subcutaneous (SC) administration per the protocol
Single ascending IV or SC administration per the protocol
Universitair Ziekenhuis Leuven Gasthuisberg Campus
Leuven, Belgium
Occurrence and severity of all treatment emergent adverse events (TEAEs)
Time frame: Through approximately day 169
Occurrence and severity of all severe adverse events (SAEs)
Time frame: Through approximately day 169
Concentrations of REGN14284 in serum over time
Time frame: Through approximately day 169
Incidence of Anti-drug antibodies (ADAs) to REGN14284 over time
Time frame: Through approximately day 90
Titer of ADAs to REGN14284 over time
Time frame: Through approximately day 90
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.