Investigating STAT3 as a Driver of Pathology in Periodontitis

University of Chile28 enrolled

Overview

Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology

Study Type

OBSERVATIONAL

Enrollment

Conditions

Periodontitis

Interventions

no interventionOTHER

no intervention

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-year-old, in good general health, and had no significant medical history. * no history of diabetes or other diseases different than periodontitis. Exclusion Criteria: * Pregnancy and lactation * Use of antibiotics, immunosuppressive agents, or probiotics within 3 months.

Locations (1)

Faculty of Dentistry, University of Chile

Santiago, Chile

Outcomes

Primary Outcomes

STAT3 detection in gingival tissues

Detection of STAT3 in gingival tissues

Time frame: 1 day

Data from ClinicalTrials.gov

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