Broccoli Sprouts for Mild Ulcerative Colitis

University of Michigan23 enrolled

Overview

The goal of this study is to determine the number of servings of broccoli sprouts sufficient to (1) increase sulforaphane levels in the stool and blood and (2) reduce inflammatory markers in patients with mild ulcerative colitis. This is a pilot feasibility study to prepare for a larger randomized controlled trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Ulcerative Colitis Ulcerative Colitis Chronic Mild

Interventions

1 Serving of broccoli sproutsDIETARY_SUPPLEMENT

Participants will take 1 serving of broccoli sprouts daily for 28 days. The sprouts will be provided by the study team along with instructions on how to prepare the steamed broccoli sprouts (i.e., steamed for 10 minutes). In addition to taking the sprouts, participants will be asked to complete food diaries and surveys, collect blood and stool samples, as well as having 2 in-person visits.

3 Servings of broccoli sproutsDIETARY_SUPPLEMENT

Participants will take 3 servings of broccoli a day for 28 days. The sprouts will be provided by the study team along with instructions on how to prepare the steamed broccoli sprouts (i.e., steamed for 10 minutes). In addition to taking the sprouts, participants will be asked to complete food diaries and surveys, collect blood and stool samples, as well as having 2 in-person visits.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Documented endoscopic diagnosis of ulcerative colitis * Currently being treated with a stable dose of 5-ASAs, steroids, or any other medication approved for ulcerative colitis * If on 5-ASA, no dose changes within 2 weeks before the Day 0 visit * If on steroids, prednisone dose not more than 20 mg daily and entocort not more than 9 mg daily, with no dose changes within 2 weeks before the Day 0 visit * All other medications require a stable dose for at least 8 weeks prior to enrollment. * No dose changes to any IBD medication anticipated for the duration of the study * Body Mass Index (BMI) values 18.5-40 kg/m2 * Not on total parenteral nutrition (TPN) or receiving tube feeds. * Ability to understand the study procedures, benefits and risks, and sign a written informed consent document. * Able to fill out questionnaires regarding dietary intakes, bowel symptoms, and study experience Exclusion Criteria: * Taking Non-steroidal anti-inflammatory drugs (NSAIDs) * Following a medically-prescribed diet, on Total parenteral nutrition (TPN), or tube feeds * Newly diagnosed (within past month), or uncontrolled diabetes or cardiovascular disease * Antibiotics in the previous 2 weeks * Consumption of more than 5 ½ cups of servings/day of fruits and vegetables as assessed by the National Cancer Institute (NCI) Diet History Questionaire III online Food Questionnaire. * A known allergy or sensitivity to cruciferous vegetables like arugula, bok choy, broccoli, cabbage, cauliflower, or collard greens

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Feasibility of adopting a steamed broccoli diet in patients with ulcerative colitis as measured by self report of difficulty eating broccoli sprouts.

Self report documented in the end of study questionnaire. The questionnaire has 11 questions with the feasibility specifically linked to question 7, "how difficult was it to eat broccoli sprouts?" The answers range from 'not at all' (1) to 'very hard' (5) on a likert like scale.

Time frame: Day 28

Feasibility of adopting a steamed broccoli diet in patients with inflammatory bowel disease ulcerative colitis as measured by participant compliance.

Compliance is collected through self-report of the number of servings consumed.

Time frame: Day 28

Levels of sulforaphane in the stool

Level recorded in micrograms/gram.

Time frame: Day 28

Levels of sulforaphane in the blood

Level recorded in micrograms/gram.

Time frame: Day 28

Data from ClinicalTrials.gov

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