Tranexamic Acid During Excisional Burn Surgery

Inclusion Criteria: * Patients scheduled for burn excisional surgery * An expected blood loss of ≥250ml based on the estimation by the performing surgeon on the basis of: (1) ≥ 2 % body surface area excision planned (100-200 cc / % total body surface area, (2) operation technique used (some techniques show more blood loss than others), (3) time after burn trauma (i.e. expected healing) * ≥18 year * informed consent of patient or legal representative * Patients or legal representative should have enough knowledge of Dutch to provide informed consent Exclusion Criteria: * Patients with a recorded coagulopathy in their history * The use of anticoagulants (except acetylsalicylic acid or (intensive) prophylaxis low molecular weight heparin \>12 hours before surgery) * Severe kidney failure (creatinine \>500 μmol/L) * Allergy for tranexamic acid * Diagnosis of acute venous-/arterial thrombosis within 3 months before inclusion * Diffuse intravascular coagulation (based on the diffuse intranasal coagulation-score \>5) * Pregnancy * Active breastfeeding * History of epilepsy