The purpose of this study is to observe the efficacy and safety of ozonated autohemotherapy in patients of post-ischemic stroke insomnia and to explore its mechanism of action.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
65
After autologous blood is mixed with ozone in vitro, the blood is injected into the patient through intravenous infusion
the Second Hospital of Jilin University
Changchun, Jilin, China
Huikang Hospital in Dehui city
Dehui, Jilin, China
Insomnia severity index
The Insomnia Severity Index Scale (ISI) will be used, which scale ranges from 0 to 28, with higher scores representing more severe insomnia. Specifically, 0-5 points represent excellent sleep quality, 6-10 points mean good sleep quality, 11-15 points indicate average sleep quality, and 16-21 points represent poor sleep quality.
Time frame: 10 days
Pittsburgh Sleep Quality Index
The Pittsburgh Sleep Quality Index Scale (PSQI) will be used, which scale ranges from 0 to 21, with higher scores representing poorer sleep quality. In detail, 0-7 points represent insomnia of no clinical significance, 8-14 points mean sub-clinical insomnia, 15-21 points indicate moderate clinical insomnia, and 22-28 points represent severe clinical insomnia.
Time frame: 10 days
Blood cell counts
Time frame: 10 days
Blood lipid level
Time frame: 10 days
tumor necrosis factor α [TNF-α], interleukin 1β [IL-1β] and interleukin 10 [IL-10]), 5-hydroxytryptamine (5-HT), norepinephrine (NE), dopamine (DA), brain-derived neurotrophic factors (BDNF).
Detection of these factors in serum of patients using Elisa kit
Time frame: 10 days
Finger oxygen saturation
Time frame: 10 days
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